Veterinary injectable furosemide in an optimal concentration for animals – the first choice for the relief of acute conditions associated with fluid retention
Furosenit-vet belongs to the fast-acting diuretics of the sulfonamide group. Furosemide
blocks the transport system of sodium, potassium, and chlorine ions in the thick segment of the ascending knee of the Henle loop, and therefore its diuretic effect depends on the veterinary drug entering the lumen of the renal tubules (due to the mechanism of anionic transport). The diuretic effect of furosemide is associated with inhibition of reabsorption sodium chloride in this section of the Henle loop. Secondary effects in relation to an increase in sodium excretion are: an increase in the amount of urine excreted (due to osmotically bound water) and an increase in potassium secretion in the distal part of the renal tubule. At the same time, the excretion of calcium and magnesium ions increases.
Furosenit-vet is used in cats and dogs for edematous syndrome of various etiologies, including pulmonary edema, chronic heart and kidney failure, nephrotic syndrome, liver diseases, severe forms of arterial hypertension and other diseases accompanied by edema.
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Indicators |
Cats and dogs |
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Dosage |
0.05-0.2 ml per 1 kg per animal body weight |
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Method and frequency of administration |
Subcutaneously, intramuscularly, intravenously with an interval of 8-24 hours |
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Treatment period |
The dosage, frequency and the course of administration are determined individually by a veterinarian depending on the indications, severity of the disease and the condition of the animal |
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In case of acute pulmonary edema (including in cardiopulmonary resuscitation), the recommended initial dosage is 0.05 - 0.1 ml per 1 kg of animal body weight (equivalent to 1-2 mg of furosemide per 1 kg of animal body weight). If no expected effect is observed during the first hour, repeated administration of the drug at a dose of 0.1 – 0.2 ml per 1 kg of animal body weight (equivalent to 2-4 mg of furosemide per 1 kg of animal body weight) is recommended. If there is no clinical effect within an hour after the second injection, the drug is repeated at the same dosage. After improvement of clinical signs, the interval between repeated administration is increased to 6-12 hours, while reducing the dosage to 0.05-0.15 ml per 1 kg of animal body weight (equivalent to 1-3 mg of furosemide per 1 kg of animal body weight).
In case of hypercalcemia, a dose of 0.1-0.2 ml per 1 kg of animal body weight (2-4 mg of furosemide per 1 kg of animal weight) is administered intravenously or subcutaneously every 8-24 hours.
In case of acute renal failure/oliguria, an intravenous dose of 0.1 ml per 1 kg of animal body weight (2 mg of furosemide per 1 kg of animal body weight) is administered. In the absence of diuresis, the administration is repeated within one hour at a dose of 0.1-0.2 ml per 1 kg of animal body weight (2-4 mg of furosemide per 1 kg of animal body weight).
It is possible to administer the drug in the form of infusion at a constant rate. In case of edema of cardiogenic nature, administer at a dose of 0.05-0.1 ml/kg/h (0.5-2 mg/kg/h). In case of other causes of edema, including renal insufficiency/oliguria, administer a dose of 0.01-0.05ml/kg/h (0.1-1 mg/kg/h).
The maximum daily dosage for an animal should not exceed 0.6 ml per 1 kg of animal body weight (12 mg of furosemide per 1 kg of animal body weight).
When administered intravenously, Furosenit-vet should be administered slowly. The rate of intravenous administration should not exceed 4 mg per minute. In animals with severe renal insufficiency, it is recommended that the rate of intravenous administration of Furosenit-vet should not exceed 2.5 mg per minute. To achieve the optimal efficacy and suppress counterregulation, prolonged intravenous infusion at a constant rate of 0.1–2 mg/kg/h is preferred.
0.9% sodium chloride solution can be used to prepare the infusion solution. The diluted solution of Furosenit-Vet should be used as soon as possible after preparation.
Contraindications and special instructions:
It should not be used simultaneously with chloral hydrate and aminoglycoside antibiotics.
Simultaneous use with oto- and nephrotoxic drugs is not recommended due to a possible increase in toxic effects; with nonsteroidal anti-inflammatory drugs and phenytoin due to increased toxicity of salicylates and a possible decrease in the efficacy of furosemide.
Furosenit-vet reduces the effectiveness of hypoglycemic agents (including insulin) and pressor amines (epinephrine, norepinephrine); in combination with cephalosporins, nephrotoxic effects may increase; in combination with cardiac glycosides, their toxicity may increase.
Furosenit-vet should be administered with caution concomitantly with angiotensin converting enzyme (ACE) inhibitors and angiotensin II receptor antagonists, as their simultaneous administration may lead to an excessive decrease in blood pressure with impaired renal function and the development of acute renal failure. The effect may be enhanced when administered concomitantly with other antihypertensive and diuretic agents, theophylline, curare-like muscle relaxants.
Glucocorticosteroids in combination with furosemide increase the risk of hypokalemia. Cyclosporine A in combination with furosemide increases the risk of impaired urate excretion by the kidneys.
Use with caution in combination with radiocontrast agents due to the increased risk of developing nephropathy.
