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Pharmacological properties
The synergistic combination of enrofloxacin and colistin sulfate provides a broad-spectrum antimicrobial activity against gram-positive and gram-negative microbes.
Enrofloxacin inhibits the activity of gyrase, an enzyme that affects the replication of DNA spiral in the nucleus of the bacterial cell, thus disrupting the protein synthesis and suppressing the growth and development of gram-positive and gram-negative bacteria including:
- Escherichia coli
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Haemophilus spp.
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Pasteurella spp.
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Salmonella spp.
-
Staphylococcus spp.
-
Streptococcus spp.
-
Clostridium perfringens
-
Bordetella spp.
-
Campylobacter spp.
-
Corynebacterium pyogenes
-
Pseudomonas aeruginosa
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Mycoplasma spp.
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Enterobacter spp.
-
Proteus mirabilis
-
Proteus vulgaris
-
Klebsiella spp.
-
Erysipelothrix spp.
-
Actinobacillus spp.
-
Fusobacterium spp.
-
Bacteroides spp.
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Indications
Enronit is prescribed to treat following diseases: for calves, and lambs – colibacillosis, salmonellosis, pasteurellosis, respiratory, and other diseases caused by enrofloxacin- and colistin sulfate-sensitive microbes; for piglets – colibacillosis, salmonellosis, pasteurellosis, respiratory, and other diseases caused by enrofloxacin- and colistin sulfate-sensitive microbes; for adult pigs – atrophic rhinitis, enzootic pneumonia, and MMA-syndrome.
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Dosage and method of administration
|
Animal
|
Method of administration
|
Dosage
|
Treatment period
|
|
Calves and lambs
|
Subcutaneously
|
0.5 ml /10 kg of animal body weight, once
|
3-5 days
|
|
Piglets
|
Intramuscularly
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|
Sows with MMA-syndrome
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1-2 days
|
As a pain reaction may occur, avoid administering more than 5 ml to calves and pigs, and more than 2.5 ml of the drug to lambs and piglets in one injection site.
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Restrictions
Contraindications and special instructions:
Avoid using Enronit simutaneously with chloramphenicol, macrolide antibiotics group and tetracycline, theophylline, and nonsteroidal anti-inflammatory agents.
Withdrawal period:
meat - 21 days
Please note: The information given on this page is for an informative purpose only. Product characteristics, packaging, label design and overall appearance may vary in different regions.
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