AMBIGRANUM-S

The anticoccidial activity of the medicinal product is due to the synergism of its active components – salinomycin (an ionophore antibiotic) and nicarbazin (a dinitrocarbanilide derivative).

The mechanism of action of salinomycin involves disruption of sodium and potassium cation transport in immature stages of coccidia, leading to their death during the schizont stage.
Nicarbazin is a synthetic anticoccidial agent whose mechanism of action consists in inhibiting the energy metabolism of the parasite. It interrupts the life cycle of coccidia at multiple developmental stages and is most active against second-generation schizonts.

The combined action of the components in the formulation not only enhances the overall anticoccidial efficacy but also slows the development of resistance.

The drug exhibits a broad spectrum of anticoccidial activity and is effective against: E. acervulina, E. brunetti, E. maxima, E. mitis, E. mivati, E. necatrix, E. praecox, E. tenella, and other coccidial species parasitizing in poultry.

Ambigranum-S is used in broilers and replacement young chicken to prevent coccidiosis.

Specie	Indication	Method of administration	Dosage	Frequency of administration
Broilers	Coccidiosis prevention	Mixed with feed	500-625 g / 1 t of feed (40-50 g of salinomycin and 40-50 g of nicarbazine / 1 t of feed)	From the first day of life during the entire growing period, excluding from the diet 5 days before slaughter
Replacement chickens				From the first day of life, excluding from the diet at least 14 days before the start of egg laying

To ensure uniform distribution of the product in the feed, stepwise mixing is recommended. The calculated dose of Ambigranum-S should be first mixed with a small portion of feed (5–10% of the total volume), then gradually added to the remaining feed under thorough mixing.

Contraindications and special instructions:
Avoid using in layers and replacement young chicken less than 14 days before the start of egg laying due to its accumulation in eggs.
The use of the drug is prohibited for 7 days before and 7 days after the administration of tiamulin, as well as in combination with other coccidiostats.


Withdrawal period:
meat: 5 days