AMBIGRANUM-M

The anticoccidial activity of the product is due to the synergism of its active components: monensin – a polyether ionophore antibiotic, and nicarbazin – a synthetic anticoccidial agent that inhibits the parasite’s energy metabolism.

Both monensin and nicarbazin are effective against all species of coccidia parasitizing in poultry, including Eimeria tenella, E. necatrix, E. acervulina, E. brunetti, E. mivati, E. maxima, as well as Eimeria adenoides, E. meleagrimitis, and E. gallopavonis.

The mechanism of monensin action involves disruption of sodium and potassium ion transport in immature stages of coccidia, leading to their death during the schizont stage.
The mechanism of nicarbazin action consists in inhibiting the parasite’s energy metabolism; it interrupts the coccidial life cycle at multiple developmental stages and is most active against second-generation schizonts.

The combined action of these components not only enhances the overall anticoccidial efficacy but also delays the development of resistance.

Ambigranum-M is used in broilers, replacement young chicken and and turkeys up to 16 weeks of age to prevent coccidiosis.

Specie	Indication	Method of administration	Dosage	Frequency of administration
Broilers	Coccidiosis  prevention	Mixed with  feed	500-625 g / 1 t of feed (40-50 g of monenzine and 40-50 g of nicarbazine / 1 t of feed)	From the first day of life  during the entire growing  period, excluding from the diet 5 days before  slaughter
Replacement chickens				From the first day of life,  excluding from the diet at least 14 days before the  start of egg laying
Turkeys				From day one up to 16 weeks of age

To ensure uniform distribution of the product in the feed, stepwise mixing is recommended. The calculated dose of Ambigranum-M should be first mixed with a small portion of feed (5-10% of the total volume), then gradually added to the remaining feed under thorough mixing.

Contraindications and special instructions:
Avoid using in layers, replacement young chicken and turkeys up to 16 weeks of age due to its accumulation in eggs.
The use of the drug is prohibited for 7 days before and 7 days after the administration of tiamulin, as well as in combination with other coccidiostats.


Withdrawal period:
meat: 5 days