Xylanit

Ease of action
Xylanit. Photo1
Хylazine hydrochloride

An effective and safe myorelaxational and sedative drug

Reduces anxiety of animals during veterinary treatments

Safely immobilizes animals for light surgical interventions


  • Description
  • An effective and safe myorelaxational and sedative drug that reduces anxiety and immobilizes the animal during veterinary treatments. It is a clear colorless liquid.

    Xylanit is produced as a sterile solution, packaged in 50 ml dark glass bottles, sealed with rubber stoppers, reinforced with aluminum caps.

    Xylanit
  • Composition
  • Composition
    1 ml
    Xylanit

    20 mg xylazine

  • Pharmacological properties
  • Pharmacological properties

    Xylazine hydrochloride, an active substance of this drug, is an antagonist to central α2-adrenoceptor; it has sedative, myorelaxant and anesthetic properities and is able to stimulate both central and peripheral α-receptors. After parenterical application, a dissociated anesthesia quickly takes place.

    After intramuscular or subdermal application, Xylanit’s properties start to take effect after 5-20 minutes; in case of subdermal application, they start to take effect after 1-5 minutes. The duration od the sedative effect depends on the animal: for cattle it lasts from 30 minutes to 5 hours; for horses – from 30 minutes to 1 hour; for small cattle – from 1 to 2 hours. The duration of the anesthetic effect also varies: for cattle it lasts up to 45 minutes; for small cattle – from 15 to 30 minutes; for horses – from 5 to 20 minutes depending on the dose and individual sensitivity of an animal.

    Neuromuscular relaxation usually occurs after 20-50 minutes. Xylazine hydrochloride enhances effects of tranquilizers, cataleptic and anesthetic drugs, that is why it should be used very carefully with these groups of drugs.

  • Indications
  • Indications

    Xylanit can be used as a sedative, anesthetic or myorelaxant drug for clinical analysis and X-ray study of farm animals, dogs and cats and immobilization of anxious and aggressive animals (including for transportation purposes); and as a premedicant for surgical operations, painful procedure and general anesthesia.

  • Dosage and route of administration
  • Dosage and route of administration

    Xylanit shall be applied intramuscularly or intravenously (slowly, during 1-2 minutes).
    For cattle, Xylanit shall be applied intramuscularly with the following dosage: 0.25 – 1.5 ml per 100 kg of animal weight (0.05-0.3 mg of xylazine hydrochloride per 1 kg of animal weight) depending on the operation. Depending on the applied dose of Xylanit, the animal may experience sedative and myorelaxant effects of various strength:


    a) if the applied dose is 0.25 ml per 100 kg, the animal shall experience a light sedative effect, a decrease in muscular tonus and shall not change its body position. This dose is used to calm an animal.
    b) if the applied dose is 0.5 ml per 100 kg, the animal shall experience a moderate sedative effect, a significant decrease in muscular tonus (the animal usually remains in a vertical position) and a small analgesic effect. This dose is used for clinical examination and short surgical operations (mostly those that are performed with local anesthesia).

    c) if the applied dose is 1.0 ml per 100 kg, the animal shall experience a considerable sedative effect and decrease in muscular tonus (the animal lies on the ground) and a strong analgesic effect. This dose is used for long surgical operations, possibly performed with local or general anesthesia.
    d) if the applied dose is 1.5 ml per 100 kg, the animal shall experience a strong sedative effect, total decrease in muscular tonus and a strong analgesic effect. This dose is used only for adult animals with prior starvation for very painful and long surgical operations and for obstetric aid.


    For small cattle, Xylanit shall be applied intramuscularly with the following dosage: 0.05 – 0.25 ml per 10 kg of animal weight (0.1-0.5 mg of xylazine hydrochloride per 1 kg of animal weight) depending on the relevant operation.
    For horses, Xylanit shall be applied either intramuscularly with the following dosage: 7.5 – 15.0 ml per 100 kg of animal weight (0.15-0.3 mg of xylazine hydrochloride per 1 kg of animal weight) – or intravenously (slowly) with the following dosage: 3.0 – 5.0 ml per 100 kg of animal weight (0.6-1.0 mg of xylazine hydrochloride per 1 kg of animal weight) - depending on the relevant operation and the type of the higher nervous system activity of the treated animal.
    The sedative effect is usually achieved in 5 minutes after the injection of the drug; it lasts for approximately 20 minutes. Very excitable animals shall receive maximal doses of Xylanit; it is not recommended to introduce the drug to animals’ backs.

    For dogs, in cases of non-painful operations Xylanit shall be applied intramuscularly with the following dosage: 0.5-1.0 ml per 10 kg of animal weight (1-2 mg of xylazine hydrochloride per 1 kg of animal weight). For cats, Xylanit shall be applied either intramuscularly or subdermally with the following dosage: 0.15 ml per 1 kg of animal weight (3 mg of xylazine hydrochloride per 1 kg of animal weight),
    In case of painful operations, Xylanit shall be applied in conjunction with other medical drugs (barbiturates, analgesics or local anesthetics).
    Barbiturate-induced anesthetics shall be administered no less than after 20 minutes of Xylanit application, i.e. after the strong sedative. If these conditions are met, barbiturate concentration can be reduced by 2-3 times.
    The treated animals shall not be disturbed until Xylanit have fully reacted. If the required degree of sedation has not been achieved, it is not recommended to apply additional injections.
    Application of higher doses of Xylanit may be performed only within 24 hours after the animal’s physiological state has completely recovered.
    After application of Xylanit, the treated animal shall be observed until complete recovery of the physiological state.
    If Xylanit has to be applied simultaneously with cataleptic and anesthetic drugs, their doses shall be decreased by 2 or 3 times from the amount indicated in this document.
    After application of Xylanit, some animals may experience temporary decrease in blood pressure and increasement in pulse and respiratory movements. These symptoms shall disappear on their own without application of other veterinary drugs.
    In extreme cases of respiratory distress, affected animal’s chest shall be massaged to restore normal breathing.
    High doses of Xylanit may cause hyper salivation of cattle. For cattle, if the operation has to be performed in lateral or back position, the animal’s chest has to be supported while head and neck have to be bowed, if possible, to avoid aspiration with saliva or ruminal liquid. Atropin sulfate can be effectively used to prevent excessive salivation. In order to prevent vomiting, cats and dogs shall be starved for 6-24 hours before application of Xylanit.
    In case of overdose and respiratory failure, the animal shall receive a cold shower and be treated with artificial respiration. Yohimbine, Tolazoline and Atipamezole (blockirators of α-adrenoceptor) are specific antidotes of xylazine hydrochloride and they shall be applied to animals according the instructions.

  • Restrictions
  • Restrictions

    Slaughter of animals for meat is permitted not earlier than 5 days after the last injection of Xylanit. Meat from animals, forcedly slaughtered before the expiry of the stated period, can be used as feed for fur animals. The milk of dairy animals may be used for food purposes not earlier than 4 days after the last administration of Xylanit. The milk obtained during the treatment and within 4 days after the last injection, can be used for animal feed after heat treatment.