Uteroton

Safeguarding generations

Propranolol

A non-hormonal drug used to induce labour, to prevent and treat gynecological diseases in animals, and to increase fertility rate.

Stimulation of soft long contractions of the uterine myometrium up to 6 to 8 hours (compared to the classic oxytocin therapy)

Effect on β-adrenoreceptors without blocking the work of the endocrine system as compared with hormone therapy

Increased cattle fertility by 20.4% due to uterine myometrium stimulation after the first insemination

Reduced incidence of uterus subinvolution by about 2 times as compared with oxytocin

Reduced incidence of MMAsyndrome by 1.7 to 2.2 times

Strong anti-stress effect.

Description
A non-hormonal drug used to induce labour, to prevent and treat gynecological diseases in animals, and to increase fertility rate.

Uteroton is a transparent colourless solution for injection.

Packing: 100 mLglass bottles.
Composition
Composition

1 ml
Uteroton

5 mg propranolol
Pharmacological properties
Pharmacological properties

Uteroton blockades beta-adrenoceptors of myometrium, which promotes endogenic oxytocin activity, thus promoting retraction of uterine smooth muscles and mammary glands. Uteroton is an antagonist of catecholamines; it has a great antistress activity.
Indications
Indications

Uteroton is prescribed to stimulate labour in atony and hypotony of the uterus; to prevent the retention of placenta and uterus subinvolution; to increase fertility; for extraction of embryos from donor cows, as a part of combination therapy for the treatment of postpartum endometritis and metritis-mastitis-agalactia (MMA) syndrome in sows.
Dosage and route of administration

Dosage and route of administration

Therapeutic indications	Dose per animal, ml
Therapeutic indications	Cow	Mare	Sow	Ewe
Stimulation of labor activity and prevention of post-parturient complications – once, on the day of delivery	10	10	5	1
Retention of afterbirth, thrice with 12 hour intervals	10	10	5	1
Treating subinvolution of uterus	10	10	5	1
Treatment and prevention of postpartum endometritis	10	10	5	1
Prevention of MMA syndrome	-	-	5	-
Artificial insemination and mating (in order to increase breeding efficiency)	5	5	5	1
Embryo transplantation to donor cows – in 10-15 minutes before embryo flushing	5	-	-	-

Restrictions
Restrictions

CONTRAINDICATIONS

Avoid using Uteroton in pregnant and young animals.

Avoid using the drug concurrently with adrenergic agonists, as propranolol prolongs the action of non-depolarizing muscle relaxants. When used concurrently with propranolol, sedatives, and sleeping pills enhance the inhibitory effect on the central nervous system.

When, concurrently with propranolol, iodine-containing drugs are administered intravenously or intramuscularly, the risk of anaphylactic reactions increases.

RESTRICTIONS

No restrictions for meat and milk consumption are set.

SHELF LIFE

3 years from the date of manufacture; after first opening - 14 days.

Description
Composition
Pharmacological properties
Indications
Dosage and route of administration
Restrictions

A non-hormonal drug used to induce labour, to prevent and treat gynecological diseases in animals, and to increase fertility rate.

Uteroton is a transparent colourless solution for injection.

Packing: 100 mLglass bottles.

Composition

1 ml

Uteroton

5 mg propranolol

Pharmacological properties

Uteroton blockades beta-adrenoceptors of myometrium, which promotes endogenic oxytocin activity, thus promoting retraction of uterine smooth muscles and mammary glands. Uteroton is an antagonist of catecholamines; it has a great antistress activity.

Indications

Uteroton is prescribed to stimulate labour in atony and hypotony of the uterus; to prevent the retention of placenta and uterus subinvolution; to increase fertility; for extraction of embryos from donor cows, as a part of combination therapy for the treatment of postpartum endometritis and metritis-mastitis-agalactia (MMA) syndrome in sows.

Video

Dosage and route of administration

Therapeutic indications	Dose per animal, ml
Therapeutic indications	Cow	Mare	Sow	Ewe
Stimulation of labor activity and prevention of post-parturient complications – once, on the day of delivery	10	10	5	1
Retention of afterbirth, thrice with 12 hour intervals	10	10	5	1
Treating subinvolution of uterus	10	10	5	1
Treatment and prevention of postpartum endometritis	10	10	5	1
Prevention of MMA syndrome	-	-	5	-
Artificial insemination and mating (in order to increase breeding efficiency)	5	5	5	1
Embryo transplantation to donor cows – in 10-15 minutes before embryo flushing	5	-	-	-

Restrictions

CONTRAINDICATIONS

Avoid using Uteroton in pregnant and young animals.

Avoid using the drug concurrently with adrenergic agonists, as propranolol prolongs the action of non-depolarizing muscle relaxants. When used concurrently with propranolol, sedatives, and sleeping pills enhance the inhibitory effect on the central nervous system.

When, concurrently with propranolol, iodine-containing drugs are administered intravenously or intramuscularly, the risk of anaphylactic reactions increases.

RESTRICTIONS

No restrictions for meat and milk consumption are set.

SHELF LIFE

3 years from the date of manufacture; after first opening - 14 days.

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