Tialong 80% belongs to antibiotics of the pleuromutilin group.
Tiamulin, which is formulated into the drug, is a broad-spectrum antibiotic of the pleuromutilin group that is active against mycoplasms including Mycoplasma hyopneumoniae, M. hyorhinis, M. hyosynoviae, M. synoviae, M. gallisepticum, M.meleagridis, Brachyspira (Brachyspira hyodysenteriae, Br. innocens, Br. pilosicoli, Br. suis), gram-positive aerobes including Staphylococcus spp., Streptococcus spp. Corynebacterium pyogenes, and anaerobes (Clostridium perfringens), gram-negative anaerobes including Lawsonia intracellularis, Bacteroides spp., Fusobacterium spp. and aerobes Actinobacillus pleuropneumoniae, Pasteurella multocida. (Erysipelothrix spp., Listeria spp., Klebsiella pneumoniae, Campylobacter).
The bacteriostatic action mechanism involves the inhibition of protein synthesis on bacterial cell ribosomes.
After oral administration of the drug, tiamulin is well absorbed in the gastrointestinal tract and penetrates into most organs and tissues of the body reaching maximal concentrations in pigs in 2 hours and remains at therapeutic level for 18-24 hours. Tiamulin is metabolized in the liver into inactive metabolites that are excreted from the body mainly with feces and to a lesser extent with urine.