Sepranol

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Chlorhexidine hydrochloride, propranolol hydrochloride

A safe antibacterial obstetric-gynecological drug that stimulates uterus activity to prevent and treat of endometritis of cows

No antibiotics and hormones in the composition

Stimulated expulsion of afterbirth

Effective against most of bacterial agents as well as fungi of the Candida family

Prevention of postpartum endometritis1

Effect spreading over the entire uterine cavity due to foam-forming composition.






1 - Due to the broad antibacterial and antimycotic spectrum and the strengthening of uterine contractions during prophylactic treatments 

  • Description

  • A safe antibacterial obstetric-gynecological drug that stimulates uterus activity to prevent and treat of endometritis of cows.

    Sepranol is flat light yellow suppositories.

    Packing: 2 suppositories per foil blister, 5 blisters per cardboard pack.

    Sepranol
  • Composition
  • Composition
    1 tablet
    Sepranol

    60 mg chlorhexidine

    343 mg propranolol

  • Pharmacological properties
  • Pharmacological properties

    Chlorhexidine hydrochloride is very effective against a wide range of Gram-positive and Gram-negative bacteria, protozoa, and fungi. Chlorhexidine acts by disrupting the plasma membrane of bacterial cells.

    Propranolol hydrochloride stimulates uterine activity and is a beta-blocker of myometrium adrenergic receptors.

  • Indications
  • Indications

    Sepranol is prescribed for cows as an afterbirth expulsion stimulant as well as to prevent and treat acute postpartum endometritis, and endometritis caused by microorganisms sensitive to chlorhexidine hydrochloride.

  • Dosage and route of administration
  • Dosage and route of administration
     Animal species  Indications  Dosage  Treatment period
     Cattle          For afterbirth expulsion  2 suppositories, by intrauterine route          Once
     As a preventative measure against acute postpartum endometritis  Once in 2 to 4 hours, after afterbirth expulsion
     As a therapeutic measure against acute postpartum endometritis  2 times, with a 24-hour interval
     As a therapeutic measure against chronic endometritis  3 times, with a 24-hour interval
     As a therapeutic measure against other inflammatory diseases of the uterus (including those of fungal origin)  3 to 5 times, with a 24-hour interval

    If the cervix is closed and it is impossible to administer suppositories, the drug is recommended for use as a solution.

    To prepare the solution: 2 suppositories are dissolved in 150 to 200 mL of sterile water or saline preheated up to 40°C.


    2 - Prevention of postpartum endometritis was studied in black-and-white Hungarian cows aged 3 to 5 years, with average fatness and body weight of 450 kg and kept in the farm (Marksovsky district, Saratov region).

    3 - M.I. Safarova, I.Yu. Pankov, M.N. Panfilova, V.A. Sidorkin Sepranol for the treatment of cows with purulent endometritis complicated with mycoses // Veterinariya Journal, No. 11.- 2013.- p. 33-37


  • Restrictions
  • Restrictions

    The products for human consumption obtained from animals during or after the treatment with Sepranol is permissible no earlier than 48 hours after the last dose of the medication was administered. In the case of forced slaughter of animals before the established deadlines, the meat (as well as the milk) can be used for feeding fur-bearing animals. 

    CONTRAINDICATIONS

    Hypersensitivity of an animal to the drug components. Avoid using the drug concurrently with other intra-uterine drugs.

    SHELF LIFE

    18 months from the date of manufacture

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