The first injectable drug based on an active albendazole metabolite
Comprehensive effect against all types of helminthes
Efficacy of up to 98 to 100%1
Immediate action and high bioavailability
No resistance to other benzimidazoles.
A high-performance, next-generation anthelmintic drug based on an active albendazole derivative, which overcomes resistance to benzimidazoles.
Ricazol is a clear yellow pink to brown liquid.
Packing: 100 mL capacity glass bottles sealed with rubber stoppers and flip-off caps.
100 mg ricobendazole
Ricazol belongs to the group of broad-spectrum anthelmintic drugs. Ricobendazole has a broad-spectrum anthelmintic action; the drug is active against mature and immature nematodes (Dictyocaulus, Haemonchus, Ostertagia, Thelazia, Trichostrongylus, Nematodirus, Cooperia, Oesophagostomum, Bunostomum, Chabertia, etc.), cestodes (Moniezia, Avitellinae, Thysaniezia, etc.), as well as mature trematodes (Fasciola, Paramphistom, and Dicrocoelium); it also has an egg-killing effect and reduces pasture contamination with helminth eggs.
The drug is well absorbed and spread through all organs and tissues of the body. The maximum concentration in the blood is achieved in 8 hours.
Mode of action: the anthelmintic activity of ricobendazole is associated with selective inhibition of beta-tubulin polymerization, which leads to the destruction of cytoplasmic microtubules of helminth intestinal cells; it inhibits glucose transport and its disposal, and inhibits the ATPsynthesis; it blocks the movement of secretory granules and other organelles within the muscle cells of the worms, disrupting the permeability of cell membranes and muscle innervation, thus causing paralysis and death of parasitic agents.
In the liver, ricobendazole is rapidly converted into albendazole sulfone and other oxidized products. The metabolites are mainly excreted with bile; only small amount of the drug is excreted with urine; in lactating animals, it is partly excreted with milk.
In case of administration of the veterinary drug at a dose, exceeding 5 mL in sheep and goats and 15 mL in cattle, injections should be done into several injection sites. In cold weather, before administering, the drug shall be preheated to 20 to 25 ˚С.
Maximum blood concentration achieved
Ricobendazole is a unique agent, as it is an active ingredient by its very nature, while albendazole requires to be activated by a whole chain of biochemical transformations occurred within the animal body.
Ricazol is prescribed for cattle and small ruminants to treat nematodosis, cestodiasis, and distomiasis.
Animal dehelminthization shall be carried out as indicated; for the prevention purposes: in spring before pasturing and in autumn before maintaining animals in stables.
Comparative antihelminthic activity attributed to Ricazol and an albendazole-based drug
The efficacy in deworming due to Ricazol injectable exceeds that of albendazole, administered orally.
Animal species |
Indications |
Route of administration |
Dosage |
Frequency of administration |
Cattle |
Monieziasis, pulmonary and gastrointestinal nematodoses |
Intramuscularly |
1 mL/25 kg |
Once |
Trichuriasis |
1 mL/20 kg |
|||
Chronic fascioliasis, paramphistomatosis, dicroceliosis |
1 mL/12,5 kg |
|||
Sheep and goats |
Monieziasis, thysanieziasis, avitellinosis, pulmonary and gastrointestinal nematodoses |
1 mL/25 kg |
||
Chronic fascioliasis, dicroceliosis, paramphistomatosis, trichuriasis |
1 mL/12,5 kg |
Hypersensitivity of an animal to ricobendazole. Avoid using the drug at acute distomatosis; during the breeding period; in pregnant cows during the first trimester, in pregnant sheep during the first half of gestation, as well as in debilitated and sick animals
Treated animals can be slaughtered for human consumption no earlier than 30 days after deworming. In the case of forced slaughter of animals before the established deadlines, the meat can be used for feeding fur-bearing animals.
Avoid using the milk, obtained from treated milked animals, for human consumption within 5 days after deworming. Taken before expiration of the restriction period, the milk can be used for animal feeding after boiling.
2 years from the date of manufacture; after first opening - maximum 30 days
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