Ricazol belongs to the group of broad-spectrum anthelmintic drugs. Ricobendazole has a broad-spectrum anthelmintic action; the drug is active against mature and immature nematodes (Dictyocaulus, Haemonchus, Ostertagia, Thelazia, Trichostrongylus, Nematodirus, Cooperia, Oesophagostomum, Bunostomum, Chabertia, etc.), cestodes (Moniezia, Avitellinae, Thysaniezia, etc.), as well as mature trematodes (Fasciola, Paramphistom, and Dicrocoelium); it also has an egg-killing effect and reduces pasture contamination with helminth eggs.
The drug is well absorbed and spread through all organs and tissues of the body. The maximum concentration in the blood is achieved in 8 hours.
Mode of action: the anthelmintic activity of ricobendazole is associated with selective inhibition of beta-tubulin polymerization, which leads to the destruction of cytoplasmic microtubules of helminth intestinal cells; it inhibits glucose transport and its disposal, and inhibits the ATPsynthesis; it blocks the movement of secretory granules and other organelles within the muscle cells of the worms, disrupting the permeability of cell membranes and muscle innervation, thus causing paralysis and death of parasitic agents.
In the liver, ricobendazole is rapidly converted into albendazole sulfone and other oxidized products. The metabolites are mainly excreted with bile; only small amount of the drug is excreted with urine; in lactating animals, it is partly excreted with milk.
In case of administration of the veterinary drug at a dose, exceeding 5 mL in sheep and goats and 15 mL in cattle, injections should be done into several injection sites. In cold weather, before administering, the drug shall be preheated to 20 to 25 ˚С.
Maximum blood concentration achieved
Ricobendazole is a unique agent, as it is an active ingredient by its very nature, while albendazole requires to be activated by a whole chain of biochemical transformations occurred within the animal body.