The first injectable drug based on an active albendazole metabolite
Joint effect on all types of helminthes
Efficacy up to 98-100%
Immediate action and high bioavailability
Overcoming resistance to benzimidazoles
A high-performance, next-generation anthelmintic drug based on an active albendazole derivative, which overcomes resistance to benzimidazoles.
On appearance, the drug is a clear, yellow-pink to yellow liquid.
Ricazol is filled in 100 ml capacity glass vials sealed with flip-off caps.
100 mg ricobendazole
Ricazol belongs to the group of broad-spectrum anthelmintic drugs. Ricobendazole has broad-spectrum anthelmintic action; the drug is active against mature and immature nematodes (Dictyocaulus, Haemonchus, Ostertagia, Thelazia, Trichostrongylus, Nematodirus, Cooperia, Oesophagostomum, Bunostomum, Chabertia etc.), tapeworms (Moniezia, Avitellinae, Thysaniezia etc.), as well as mature flukes (Fasciola, Paramphistom, and Dicrocoelium), has an egg-killing effect; it reduces pasture contamination with helminth eggs.
The mechanism of action of ricobendazole (albendazole sulfoxide) ensuring its anthelmintic activity is associated with selective inhibition of beta-tubulin polymerization, which leads to the destruction of cytoplasmic microtubules of helminth intestinal cells; it inhibits glucose transport and disposal, and inhibits the ATP synthesis; it blocks the movement of secretory granules and other organelles in the muscle cells of the worms, disrupting the permeability of cell membranes and muscle innervation, which causes paralysis and death of the parasites.
The drug is well absorbed and distributed in all organs and tissues of the body. The maximum concentration in the blood is achieved after 8 hours. In the liver, Ricobendazole is rapidly converted into albendazole sulfone and other oxidized products. Albendazole metabolites are mainly excreted with bile; only small amount of the drug is excreted with urine; in lactating animals, partly with milk.
Ricazol shall be administered to cattle and small ruminants for treatment of nematodosis, cestodiasis, and distomiasis. Animal dehelminthization shall be carried out as indicated; for the prevention purposes: in spring, before driving out and in autumn, before stall housing.
The drug shall be administered intramuscularly once, individually.
Cattle: Ricazol shall be used for treatment of monieziasis, pulmonary and intestinal nematodes, at a dose of 1 mL per 25 kg of body weight (4 mg/kg of ricobendazole); of whip-worm infection, at a dose of 1 mL per 20 kg of body weight (5 mg/kg of ricobendazole); of chronic fluke disease, paramphistomatosis, and dicroceliasis, at a dose of 1 mL of 12.5 kg of animal body weight (8 mg/kg of ricobendazole).
Small ruminants: Ricazol shall be used for treatment of monieziasis, thysanieziosis, avitellinosis, pulmonary and intestinal nematodes, at a dose of 1 mL per 25 kg of animal body weight (4 mg/kg of ricobendazole); of chronic fluke disease, dicroceliasis, paramphistomatosis, and whip-worm infection, at a dose of 1 mL per 12.5 kg of animal body weight (8 mg/kg of ricobendazole).
Should the drug be administered in the amount exceeding 5 mL for sheep and goats, 15 mL for cattle, the injection shall be carried out at several sites. In the cold weather, the drug shall be preheated to 20-25 ˚С before administration.
Animal slaughter for meat, after the dehelmintization, shall be allowed not earlier than in 30 days. Meat from animals slaughtered till expiration of the specified term may be used as food for fur-bearing animals.
Milk from dairy animals may not be used as food for 5 days after the dehelmintization. Milk produced before the expiration of the specified term may be used, once heat treated, as food for animals.
* The resulting figure at nematodosis, dictyocaulosis, monieziasis and other intestinal strongylatosis, when applying ricobendazole in a dose of 4 mg / kg of animal body weight.
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