Ricazol

No compromises

Ricobendazole

A high-performance, next-generation anthelmintic drug based on an active albendazole derivative, which overcomes resistance to benzimidazoles.

The first injectable drug based on an active albendazole metabolite

Comprehensive effect against all types of helminthes

Efficacy of up to 98 to 100%¹

Immediate action and high bioavailability

No resistance to other benzimidazoles.

¹ - The indicator was obtained, when administering ricobendazole at a dose of 4 mg/kg of animal body weight to treat nematodirosis, dictyocaulosis, monieziasis, and strongylatosis.

Description
A high-performance, next-generation anthelmintic drug based on an active albendazole derivative, which overcomes resistance to benzimidazoles.

Ricazol is a clear yellow pink to brown liquid.

Packing: 100 mL capacity glass bottles sealed with rubber stoppers and flip-off caps.
Composition
Composition

1 ml
Ricazol

100 mg ricobendazole
Pharmacological properties
Pharmacological properties

Ricazol belongs to the group of broad-spectrum anthelmintic drugs. Ricobendazole has a broad-spectrum anthelmintic action; the drug is active against mature and immature nematodes (Dictyocaulus, Haemonchus, Ostertagia, Thelazia, Trichostrongylus, Nematodirus, Cooperia, Oesophagostomum, Bunostomum, Chabertia, etc.), cestodes (Moniezia, Avitellinae, Thysaniezia, etc.), as well as mature trematodes (Fasciola, Paramphistom, and Dicrocoelium); it also has an egg-killing effect and reduces pasture contamination with helminth eggs.

The drug is well absorbed and spread through all organs and tissues of the body. The maximum concentration in the blood is achieved in 8 hours.

Mode of action: the anthelmintic activity of ricobendazole is associated with selective inhibition of beta-tubulin polymerization, which leads to the destruction of cytoplasmic microtubules of helminth intestinal cells; it inhibits glucose transport and its disposal, and inhibits the ATPsynthesis; it blocks the movement of secretory granules and other organelles within the muscle cells of the worms, disrupting the permeability of cell membranes and muscle innervation, thus causing paralysis and death of parasitic agents.

In the liver, ricobendazole is rapidly converted into albendazole sulfone and other oxidized products. The metabolites are mainly excreted with bile; only small amount of the drug is excreted with urine; in lactating animals, it is partly excreted with milk.

In case of administration of the veterinary drug at a dose, exceeding 5 mL in sheep and goats and 15 mL in cattle, injections should be done into several injection sites. In cold weather, before administering, the drug shall be preheated to 20 to 25 ˚С.

Maximum blood concentration achieved

Ricobendazole is a unique agent, as it is an active ingredient by its very nature, while albendazole requires to be activated by a whole chain of biochemical transformations occurred within the animal body.
Indications
Indications

Ricazol is prescribed for cattle and small ruminants to treat nematodosis, cestodiasis, and distomiasis.

Animal dehelminthization shall be carried out as indicated; for the prevention purposes: in spring before pasturing and in autumn before maintaining animals in stables.

Comparative antihelminthic activity attributed to Ricazol and an albendazole-based drug

The efficacy in deworming due to Ricazol injectable exceeds that of albendazole, administered orally.
Dosage and route of administration

Dosage and route of administration

Animal species	Indications	Route of administration	Dosage	Frequency of administration
Cattle	Monieziasis, pulmonary and gastrointestinal nematodoses	Intramuscularly	1 mL/25 kg	Once
	Trichuriasis		1 mL/20 kg
	Chronic fascioliasis, paramphistomatosis, dicroceliosis		1 mL/12,5 kg
Sheep and goats	Monieziasis, thysanieziasis, avitellinosis, pulmonary and gastrointestinal nematodoses		1 mL/25 kg
Sheep and goats	Chronic fascioliasis, dicroceliosis, paramphistomatosis, trichuriasis		1 mL/12,5 kg

CONTRAINDICATIONS

Hypersensitivity of an animal to ricobendazole. Avoid using the drug at acute distomatosis; during the breeding period; in pregnant cows during the first trimester, in pregnant sheep during the first half of gestation, as well as in debilitated and sick animals

Restrictions
Restrictions

Treated animals can be slaughtered for human consumption no earlier than 30 days after deworming. In the case of forced slaughter of animals before the established deadlines, the meat can be used for feeding fur-bearing animals.

Avoid using the milk, obtained from treated milked animals, for human consumption within 5 days after deworming. Taken before expiration of the restriction period, the milk can be used for animal feeding after boiling.

SHELF LIFE

2 years from the date of manufacture; after first opening - maximum 30 days

Description
Composition
Pharmacological properties
Indications
Dosage and route of administration
Restrictions

A high-performance, next-generation anthelmintic drug based on an active albendazole derivative, which overcomes resistance to benzimidazoles.

Ricazol is a clear yellow pink to brown liquid.

Packing: 100 mL capacity glass bottles sealed with rubber stoppers and flip-off caps.

Composition

1 ml

Ricazol

100 mg ricobendazole

Pharmacological properties

Ricazol belongs to the group of broad-spectrum anthelmintic drugs. Ricobendazole has a broad-spectrum anthelmintic action; the drug is active against mature and immature nematodes (Dictyocaulus, Haemonchus, Ostertagia, Thelazia, Trichostrongylus, Nematodirus, Cooperia, Oesophagostomum, Bunostomum, Chabertia, etc.), cestodes (Moniezia, Avitellinae, Thysaniezia, etc.), as well as mature trematodes (Fasciola, Paramphistom, and Dicrocoelium); it also has an egg-killing effect and reduces pasture contamination with helminth eggs.

The drug is well absorbed and spread through all organs and tissues of the body. The maximum concentration in the blood is achieved in 8 hours.

Mode of action: the anthelmintic activity of ricobendazole is associated with selective inhibition of beta-tubulin polymerization, which leads to the destruction of cytoplasmic microtubules of helminth intestinal cells; it inhibits glucose transport and its disposal, and inhibits the ATPsynthesis; it blocks the movement of secretory granules and other organelles within the muscle cells of the worms, disrupting the permeability of cell membranes and muscle innervation, thus causing paralysis and death of parasitic agents.

In the liver, ricobendazole is rapidly converted into albendazole sulfone and other oxidized products. The metabolites are mainly excreted with bile; only small amount of the drug is excreted with urine; in lactating animals, it is partly excreted with milk.

In case of administration of the veterinary drug at a dose, exceeding 5 mL in sheep and goats and 15 mL in cattle, injections should be done into several injection sites. In cold weather, before administering, the drug shall be preheated to 20 to 25 ˚С.

Maximum blood concentration achieved

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Ricobendazole is a unique agent, as it is an active ingredient by its very nature, while albendazole requires to be activated by a whole chain of biochemical transformations occurred within the animal body.

Indications

Ricazol is prescribed for cattle and small ruminants to treat nematodosis, cestodiasis, and distomiasis.

Animal dehelminthization shall be carried out as indicated; for the prevention purposes: in spring before pasturing and in autumn before maintaining animals in stables.

Comparative antihelminthic activity attributed to Ricazol and an albendazole-based drug

The efficacy in deworming due to Ricazol injectable exceeds that of albendazole, administered orally.

Video

Dosage and route of administration

Animal species	Indications	Route of administration	Dosage	Frequency of administration
Cattle	Monieziasis, pulmonary and gastrointestinal nematodoses	Intramuscularly	1 mL/25 kg	Once
	Trichuriasis		1 mL/20 kg
	Chronic fascioliasis, paramphistomatosis, dicroceliosis		1 mL/12,5 kg
Sheep and goats	Monieziasis, thysanieziasis, avitellinosis, pulmonary and gastrointestinal nematodoses		1 mL/25 kg
Sheep and goats	Chronic fascioliasis, dicroceliosis, paramphistomatosis, trichuriasis		1 mL/12,5 kg

CONTRAINDICATIONS

Restrictions

Treated animals can be slaughtered for human consumption no earlier than 30 days after deworming. In the case of forced slaughter of animals before the established deadlines, the meat can be used for feeding fur-bearing animals.

Avoid using the milk, obtained from treated milked animals, for human consumption within 5 days after deworming. Taken before expiration of the restriction period, the milk can be used for animal feeding after boiling.

SHELF LIFE

2 years from the date of manufacture; after first opening - maximum 30 days

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