Targeted action and long-term protection from respiratory diseases as the drug concentrates in the immune system cells
Overcoming the resistance to previous generations of macrolide antibiotics
Highly effective against mycoplasma
Balanced to be diluted in water
Highly stable in hard water.
A macrolide antibiotic with an increased efficacy for treating respiratory diseases in poultry, pigs, and cattle.
Pnevmotil is a clear light yellow to yellow brown liquid.
Packing: 100 mL and 1000 mL tightly closed and sealed bottles filled with an oral solution.
250 mg tilmicozin
Tilmicosin phosphate is an antibiotic belonging to the macrolide group, that is efficient against most Gram-positive and some Gram-negative microbes including Staphylococcus spp., Streptococcus spp., Pasteurella spp., Clostridium spp., Arcanobacterium spp. (Corynebacterium), Brachyspira hyodysenteriae, Chlamydia spp., Spirocheta spp., Actinobacillus pleuropneumoniae, Mannheimia haemolitica, and Mycoplasma spp.
Mode of action: tilmicosin inhibits bacterial growth by blocking protein synthesis in the microbial cell. Administered orally, tilmicosin phosphate is quickly absorbed in the gastrointestinal system and distributed among all organs and tissues, quickly reaching high therapeutic concentrations. Tilmicosin is excreted unchanged mostly with bile and feces and partially with urine.
Pnevmotil is prescribed for calves suffering from respiratory diseases caused by Pasteurella multocida, Mannheimia haemoli, Arcanobacterium pyogenes, Mycoplasma bovis, and Mycoplasma dyspar. It is also prescribed in the case of mixed infections, secondary infections after viral diseases, and other animal diseases caused by tilmicosin-sensitive pathogens.
Pnevmotil is prescribed for pigs to treat respiratory diseases caused by Mycoplasma hyopneumoniae, Actinobacillus pleuropneumoniae, and Pasteurella multocida. It is also prescribed in the case of mixed infections, secondary infections after viral diseases, and other animal diseases caused by tilmicosin-sensitive pathogens.
Pnevmotil is prescribed for poultry suffering from infections caused by Mycoplasma gallicepticum, Mycoplasma sinoviae, Ornithobacterium rhinotracheale, and Pasteurella multocida. It is also prescribed in the case of mixed infections, secondary infections after viral diseases, and other animal diseases caused by tilmicosin-sensitive pathogens.
Results of comparative studies regarding MICs of tilmicosin and those of tylosin for pathogens of respiratory diseases in poultry1,2,3,4
Pnevmotil has an increased efficacy compared with previous generations of macrolides.
Concentration of tilmicosin in poultry tissues after 5 days of treatment with tilmicosin5
Administered orally, tilmicosin reaches a maximum concentration within 3 to 5 days and retains a protective effect for up to 20 days to fight against pathogens of respiratory diseases in poultry.
1 - “MIC” stands for minimum inhibitory concentration, i. e. the minimum concentration of antibiotic in the culture medium, where no signs of multiplication of the selected strain are observed. It characterizes the degree of sensitivity of a pathogen to an antibiotic: the lower the MIC, the higher the sensitivity.
2 - Avian Diseases / The Minimum Inhibitory Concentration of Tilmicosin and Tylosin for Mycoplasma gallisepticum and Mycoplasma synoviae and a Comparison of Their Efficacy in the Control of Mycoplasma gallisepticum Infection in Broiler Chicks / F T. W. Jordan and B. Karen Horrocks // 1996
3 - Antimicrobial therapy in veterinary medicine /Steeve Giguère, John F. Prescott, Patricia M. Dowling. //5th ed., 2013
4 - Wseas Transactions on Biology / Phenotypic Characteristics, Antibiotic Susceptibility and Pathogenicity of Ornithobacterium rhinotracheale /Zaini Mohd-Zain, Tan Lin Jee and Kamaruzaman Jusoff //2008
5 - J. Vet. Pharmacol. Therap. Pharmacokinetics and tissue depletion of tilmicosin in turkeys/, J. A. FRICKE // 2008
Pagocytosis pattern with leukocytes enriched with tilmicosin
Due to its unique pharmacokinetic properties, Pnevmotil can be used to treat various respiratory diseases.
Pnevmotil is administered to animals orally, with potable water for 3 to 5 days successively:
to calves - individually with water or milk substitute, twice a day, at a dose being 0.5 mL per 10 kg of animal body weight (12.5 mg of tilmicosin phosphate per 1 kg of animal body weight)
to pigs - individually or in a group method, 8 mL per 10 L of water or 0.6 to 0.8 mL per 10 kg of body weight (15 to 20 mg of tilmicosin phosphate per 1 kg of animal body weight); In pigs, the therapeutic Pnevmotil solution should be the only source of drinking water during the treatment period.
to poultry - in a group method at a daily dose of 3 mL per 10 L of water (15 to 20 mg of tilmicosin phosphate per 1 kg of bird weight). In chickens, the therapeutic Pnevmotil solution should be the only source of drinking water during the treatment period.
The solution is to be prepared daily (its shelf life is up to 24 hours).
Avoid using Pnevmotil in adult ruminants with advanced cicatricial digestion, animals suffering from severe impaired liver and (or) kidney function. Also, avoid using the drug concurrently for 7 days before and 7 days after the application of ionophore anticoccidial agents, aminoglycoside antibiotics, as side effects and complications (e. g. diarrhea, anorexia, paresis, or nephrotoxic effects) are possible in animals. In order to prevent adsorption and reduce antibacterial activity, avoid using the drug concurrently with bentonite-containing drugs and feed additives. Avoid using Pnevmotil in laying hens, as tilmicosin accumulates in eggs.
Pigs and poultry can be slaughtered for human consumption not earlier than 35 days, calves - not earlier than 16 days after Pnevmotil was administered for the last time. In the case of forced slaughter of animals before the established deadlines, the meat can be used for feeding fur-bearing animals
3 years from the date of manufacture; after first opening - 3 months
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