Instruction for use of Nitamin

I. General information

1. Tradenamе of the veterinary medicinal product: Nitamin

International nonproprietary name: vitamin A, vitamin D3, vitamin E, vitamin C

2. Nitamin is a transparent liquid of yellow color. Shelf-life of the medicinal product under the specified conditions is 18 months from the date of manufacture, after first opening – 14 days.

The use of the drug Nitamin after the expiration date is prohibited.

3. Nitamin is available in 20, 50, 100 ml glass vials which are hermetically sealed with rubber stoppers and aluminum caps with first opening control clips.

4. The veterinary medicinal product is stored in sealed original package, separately from food and feed, in a dry place, protected from direct sunlight, storage temperature range: 4°С to 25°С.

5. Nitamin should be kept out of reach of children.

6. Unused product should be disposed of in accordance with the applicable legislation.

7. The veterinary drug Nitamin is available without veterinary prescription.

II. Сomposition

8. Pharmaceutical form: sterile solution for injections and oral use

1 ml of Nitamin contains vitamin A - 50000 IU, vitamin D3 – 5000 IU, vitamin E - 50 mg, vitamin C - 100 mg as active substances and excipients – up to 1 ml.

III. Pharmacological properties

9. Nitamin compensates vitamin deficiency in animal organism.

10. Vitamin A regulates structure, function and regeneration of epithelial tissues, thus increasing resistance against infection. Increased doses of Vitamin A prevent weight reduction and promote metabolism. Vitamin D3 regulation calcium and phosphor exchange and affects their absorption to gastrointestinal system, it decreases the chance of rickets formation. Vitamin E regulates redox processes and affects carbohydrate-lipid exchange and enhances effects of vitamin A and vitamin D3. Vitamin C is important for normal growth and increases protective function of animal organism.

Administration of the drug leads to quick increase of vitamin concentration in blood and vitamin accumulation in liver and other tissues, thus fully satisfying their supply for 2 months.

By the degree of its effect on the body, Nitamin is classified as a low-risk substance (IV substance hazard category according to the GOST No. 12.1.007-76).

IV. Administration procedure

11. Nitamin is used for prevention and treatment of vitamin deficiency and normalization of animal metabolism during stress, decrease of productivity and additional loads such as: pregnancy (only second half) and lactation; dysfunctions of reproductive function; transportation; diet change for fattening animals; growth inhibition and insufficient weight gain; contagious and invasive diseases; veterinary operations including preventative vaccinations and dehelminthization, surgical operations and injuries; diminished performance and decreased durability of hen’s egg shell.

12. Contraindications include hypervitaminosis or hypersensitivity to components of the drug.

13. The drug is administered intramuscularly or subcutaneously once per 4-8 weeks or orally together with drinking water or feed once per month. If the drug is used for treatment, its dose can be increased by 2-3 times. For chickens and pullets the drug is administered once, for laying hens – twice with 2 weeks interval.

The drug dosage depends on type and age of animals and method of administration. To poultry, the drug is administered orally with drinking water. In case of oral administration, the drug shall be added to feed or drinking water (it should be noted that the drug shall be added to water, not otherwise, and stirred thoroughly). The drug shall be diluted gradually. Recommended doses of veterinary drug depending of animal type, age and method of administration:

Type and age of animal

Method of administration

Intramuscular or subcutaneous, ml per 10 kg of animal weight

Oral, ml per 10 kg of animal weight

Bovine cattle, horses

0.2-0.25

0.3-0.5

calves, colts

0.2-0.5

0.5-0.6

Sheep, goats

0.5-0.8

0.75-1.25

lambs

1.5-2.0

2.0-3.0

Pigs:

sows

0.3-0.45

0.5-0.7

fattening pigs

0.2-0.3

0.2-0.5

piglets

0.4-1.0

1.0-2.0

Dogs and cats

0.2-0.3

0.3-0.6

Rabbits, fur animals

0.6-1.0

1.0-2.0

Poultry:

   Oral, ml per 1 l of water

chicken

1.0

pullets, laying hens

1.5

turkeys

2.0

14. Imperceptible overdose of the medicinal product results in violation of movements coordination, salivation, depression. Symptomatic medicines and measures are indicated, aimed at accelerated removal of the drug from the animal body.

15. No specific actions were reported at the first use and discontinuance of the drug.

16. Administration to pregnant animals is allowed only in the 2nd half of pregnancy, to lactating and young animals under control of veterinarian.

17. When a dose is missed, continue to administer the product in the same dose and according to the same schedule. It is not allowed to administer double dosage to compensate missed.

18. No adverse reactions were observed at the administration of Nitamin if administered subject to the instructions for use.

Arousal, salivation, ataxia, too rapid defecation and urination may occur in animals with increased individual sensitivity. In these cases, the use of the drug is discontinued, antihistamines are administered, symptomatic and detoxification therapy is carried out.

19. Nitamin should not be used simultaneously with corticosteroid hormones. They contribute to the elimination of vitamin D3 from the body, as well as disrupt the absorption and metabolism of calcium. Simultaneous use of the drug with cardiac glycosides may increase their toxic effects (increased risk of cardiac arrhythmias). Simultaneous use with tetracyclines increases the risk of intracranial hypertension., The drug Nitamin is used with caution at the same time with NSAIDs, cardiac glycosides – it increases the effect of the latter.

It is necessary to avoid contact of the drug solutions with disinfectants and oxidants.

20. The products made of farm animals and poultry that were administered the drug Nitamin can be used as food without any restrictions.

V. Special precautions for use

21. General rules of personal hygiene and safety measures required during work with medical agents should be followed when handling Nitamin.

22. It is prohibited to drink, smoke or eat while handling the product. Wash your hands with soap and water after handling the product.

People with hypersensitivity to the formulation constituent should avoid direct contact with the veterinary drug Nitamin. Use of the empty vials of Nitamin for domestic purposes is prohibited; they must be disposed of along with household waste.

23. In case of eye or skin contact, rinse with plenty of water. In case of allergic response or occasional contact with human body it is necessary to apply to the hospital (you should take the instructions for use of the product or the product label with you).