Neozidin

To prepare a sterile 7% solution for injection, 12.5 mL of water for injection or saline is introduced into a vial with 2.36 g of Neozidin powder, thus obtaining 14.5 mL of a ready-touse solution.

The prepared solution of Neozidin shall be stored in a hermetically sealed original vial in a dark place, at room temperature, for no more than 24 hours; or 48 hours, if stored in refrigerator. Avoid boiling or heating the solution to the temperature exceeding 37 °C.

To treat babesiosis (pyroplasmosis), fransaiellosis, or nuttalliosis, administer the Neozidin solution to animals intramuscularly at a single dose of 1 mLper 20 kg of animal body weight. To treat theileriasis, administer the Neozidin solution at a dose of 1.5 mL per 20 kg of animal body weight (i. e. 5 mg of diminazene per 1 kg); to treat trypanosomiasis caused by T. brucei (Nagana) - at a dose of 2.2 mL per 20 kg of animal body weight (i. e. 8 mg of diminazene per 1 kg).

If after first application of drug, the temperature of treated animal has not dropped and its general condition has not improved, the same dose of drug can be repeated once more after 24 hours. The treated animals should be left motionless and, additionally, depending on their physiological state, symptomatic medications (i. e. cardiac, laxatives, vitamins, trace elements) should be prescribed. In dogs, before administering Neozidin, parenteral administration of antihistamines is recommended.

As a preventative measure, Neozidin is administered once at a dose of 3.5 mg of diminazene per 1 kg of animal body weight, if animals with clinical symptoms of pyroplasmosis have been found in the herd, or if the herd has been transferred to an area endemic for blood protozoan diseases. If necessary, administration can be repeated after 10 to 15 days. Before mass treatment with Neozidin, each drug batch is first tested in a small group of animals (5 to 10 animals). If no complications are revealed within 3 days, the whole livestock may be treated with the drug. When used at the recommended doses, side effects and complications attributed to Neozidin are generally not observed. In some animals, the administration of the drug may be associated with a swelling at the injection site, that is quickly dissolved.

If the required volume of drug exceeds 10 mL in large animals and 2.5 mL in small animals, injections should be made in several injection sites to avoid any painful reaction.

The correlation between drug doses and animal body weight:

CONTRAINDICATIONS

Hypersensitivity of an animal to the drug components. Avoid using the drug concurrently with other antiprotozoal drugs. Avoid using the drug within 4 weeks after vaccination with a live vaccine against babesiosis or anaplasmosis.

The slaughter of animals is allowed no earlier than 21 days after the last dose of the product was administered. In the case of forced slaughter of animals and poultry before the established deadlines, the meat can be used for feeding fur-bearing animals or transformed to meat and bone meal.

The milk, obtained from the animals being treated with Neozidin, may be used for human consumption no earlier than 5 hours after the last dose of Neozidin was administered. Before the established deadlines, such milk can be used for animal feeding after boiling.

SHELF LIFE

2 years from the date of manufacture; the product should not be stored after opening the vial.