Meradok

A steel barrier
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Doramectin

An antiparasitic drug based on the new generation of avermectins that overcomes resistance to ivermectin and provides an extremely long protection against reinfestation.

28-day protection against re-infestation

Single-injection treatment

Overcomes ivermectin resistance

Intramuscular administration.

  • Description
  • An antiparasitic drug based on the new generation of avermectins that overcomes resistance to ivermectin and provides an extremely long protection against reinfestation.

    Meradok is a clear light yellow to yellow liquid. Packing: 100 mL hermetically sealed glass bottles.

    Meradok
  • Composition
  • Composition
    1 ml
    Meradok

    10 mg doramectin

  • Pharmacological properties
  • Pharmacological properties

    Doramectin is an antiparasitic agent of systemic effect that belong to macrocyclic lactones. Doramectin binds with muscle cell and nervous tissue receptors and increases membrane permeability for chlorine ions, causing blockage of nerve impulses that leads to paralysis and death of parasitic agents.

    Doramectin is quickly absorbed from the injection site, reaching the peak concentrations within 4 to 5 days. The medication is excreted unchanged with the feces.

    Due to its pharmacokinetic properties, concentrations of doramectin remain therapeutic for a long time in the blood of animals.

    Once administered, Meradok retains its protective effect for 28 days.

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    The duration of Meradok effect exceeds the life cycle of Sarcoptes mites, thus ensuring protection against re-infestation.

    Dynamics of changes in doramectin serum concentration after the application of Meradok 

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    When applied at recommended doses, Meradok is safe for warm-blooded animals. Injections of the drug are painless and do not cause stress in animals. Due to the reasonable dosage, Meradok is administered in one injection, thus less injuring animals. 

  • Indications
  • Indications

    Meradok is prescribed for cattle, sheep, and pigs to prevent and to treat diseases caused by nematodes affecting the gastrointestinal tract, lungs, subcutaneous tissue, tear ducts, by subcutaneous and Oestrinae larvae, lice, itch mites, and red ticks. Meradok is prescribed for cattle to treat diseases caused by:

    • gastrointestinal nematodes (mature and larvae): Ostertagia ostertagi (incl. encapsulated larvae), O. lyrata, Haemonchus placei, H. similis, Trichostrongylus axei, T. colubriformis, T. longispicularis, Mecistocirrus digitatus, Cooperia oncophora (incl. encapsulated larvae), C. pectinata, C. punctata, C. spatulata, C. sumabada (synonym: Mcmasteri), Nematodirus helvetianus, N. spathiger, Bunostomum phlebotomum, Strongyloides papillosus, Oesophagostomum radiatum, Trichocephalus discolour, Trichocephalus ovis

    • pulmonary nematodes (mature and larvae) - Dictyocaulus viviparous

    • nematodes of the tear ducts - Thelazia spp.

    • subcutaneous nematodes - Parafilaria bovicola

    • larvae of warble flies - Hypoderma bovis, Hypoderma lineatum; џ sarcoptoidea - Psoroptes bovis, Sarcoptes bovis, Chorioptes bovis

    • red ticks - Boophilus microplus

    • argasids - Ornithodouros spp.

    Meradok is prescribed for sheep to treat diseases caused by:

    • gastrointestinal nematodes - Ostertagia (Teladorsagia) circumcincta (mature and larvae, incl. those resistant to benzimidazole derivatives), Haemonchus contortus (mature and larvae), Trichostrongilus axei (mature and larvae), Т. colubriformis (mature and larvae), T. vitrinus (mature and larvae), Cooperia curticei (larvae), C. oncophora (mature and larvae), Oesophagostomum venulosum (mature), Nematodirus spp. (mature and larvae), Strongyloides papillosus

    • pulmonary nematodes - Dictyocaulus filarial

    • itch mites - Psoroptes ovis, Sarcoptes ovis

    • gasflies larvae - Oestrus ovis.

    Meradok is prescribed for pigs to treat diseases caused by:

    • gastrointestinal nematodes (mature and larvae)— Hyostrongylus rubidus, Ascaris suum, Strongyloides ransomi (mature), Oesophagostomum dentatum, Oesophagostomum quadrispinulatum, Trichocephalus suis

    • pulmonary nematodes (mature): Metastrongylus spp.

    • renal nematodes (mature): Stephanurus dentatus

    • lice—Haematopinus suis

    • itch mites—Sarcoptes scabiei. 


  • Dosage and route of administration
  • Dosage and route of administration

    Animal species

    Indications

    Route of administration

    Dosage

    Frequency of administration

    Cattle

    Nematodoses, arachnid-caused diseases

    Subcutaneously to cervical region

    1 mL/50 kg

    Once

    Small Ruminants

    Intramuscularly

    Pigs

    Nematodoses, arachnid-caused diseases

    Intramuscularly

    1 mL/33 kg

    Once

     

    CONTRAINDICATIONS

    Hypersensitivity of an animal to the drug components (the history of it). Avoid applying the drug to the animals suffering from contagious diseases and to weak animals.

    As doramectin is excreted with milk, avoid using the drug in milked and pregnant cows less than 60 days before calving or lactation; and in ewes - 70 days before lambing.

  • Restrictions
  • Restrictions

    The slaughter of cattle and sheep for human consumption is allowed no earlier than 70 days, of pigs - no earlier than 77 days after the last dose of the product was administered. In the case of forced slaughter of animals before the established deadlines, the meat can be used for feeding fur-bearing animals.

    SHELF LIFE

    3 years from the date of manufacture; after first opening - 90 days.