Lexoflon OR

Cope where others are powerless
Levofloxacin

A new generation of fluoroquinolone based on levofloxacin for oral administration to poultry and pigs.

Works against the resistance to enrofloxacin and previous generations of fluoroquinolones

Stable to the resistance development

Effective in mixed infections

Ensures rapid recovery of productivity

  • Description
  • A new generation levofloxacin-based fluoroquinolone for oral administration to poultry and pigs.
    Appearance: a clear greenish-yellow to brown-yellow solution.
    Lexoflon OR is available in 1 L polymer bottles with tamper proof screw caps.

    Lexoflon OR
  • Composition
  • Composition
    1 ml Lexoflon OR = 150 mg levofloxacin
  • Pharmacological properties
  • Pharmacological properties

    Levofloxacin contained in the drug is a broad-spectrum antibiotic of the fluoroquinolones group, which has a bactericidal action.

    Mechanism of action of levofloxacin is associated with blocking of DNA gyrase (type II topoisomerase) and type IV topoisomerase, interference with DNA supercoiling and linkage of breaks, inhibition of DNA synthesis, deep metabolic alterations in the cytoplasm, cell wall, and membranes.

    As a new generation agent, levofloxacin allows overcoming the microorganisms’ resistance to previous generations of fluoroquinolones, including enrofloxacin.

    Levofloxacin is rapidly and almost completely absorbed after oral intake. Food intake has little effect on the rate and completeness of absorption. Bioavailability of levofloxacin after oral intake is 99%, the concentration in serum reaches its maximum in 2 hours after administration, the elimination half-life is 7 hours. It penetrates easily into the organs and tissues: the lungs, bronchial mucosa, sputum, organs of the genitourinary system, polymorphonuclear leukocytes, alveolar macrophages. It is excreted from the body mainly by the kidneys through glomerular filtration or tubular secretion. After oral intake, it is mainly excreted in urine unchanged within 48 hours. A minor amount was detected in feces over a period of 72 hours.

    Lexoflon OR is the drug of choice as an antibacterial agent when resistance occurs to the cultures of E. coli, Salmonella spp, Pseudomonas aeruginosa, Proteus mirabilis.

  • Indications
  • Indications

    Levofloxacin contained in the drug is a broad-spectrum antibiotic of the fluoroquinolones group, which has a bactericidal action.

    Mechanism of action of levofloxacin is associated with blocking of DNA gyrase (type II topoisomerase) and type IV topoisomerase, interference with DNA supercoiling and linkage of breaks, inhibition of DNA synthesis, deep metabolic alterations in the cytoplasm, cell wall, and membranes.

    As a new generation agent, levofloxacin allows overcoming the microorganisms’ resistance to previous generations of fluoroquinolones, including enrofloxacin.

    Levofloxacin is rapidly and almost completely absorbed after oral intake. Food intake has little effect on the rate and completeness of absorption. Bioavailability of levofloxacin after oral intake is 99%, the concentration in serum reaches its maximum in 2 hours after administration, the elimination half-life is 7 hours. It penetrates easily into the organs and tissues: the lungs, bronchial mucosa, sputum, organs of the genitourinary system, polymorphonuclear leukocytes, alveolar macrophages. It is excreted from the body mainly by the kidneys through glomerular filtration or tubular secretion. After oral intake, it is mainly excreted in urine unchanged within 48 hours. A minor amount was detected in feces over a period of 72 hours.

    Lexoflon OR is the drug of choice as an antibacterial agent when resistance occurs to the cultures of E. coli, Salmonella spp, Pseudomonas aeruginosa, Proteus mirabilis.

  • Dosage and route of administration
  • Dosage and route of administration

    Administer orally at a rate to provide 1 mL / 20 kg of body weight for 3-5 days. Oral solution resistant to hard water for fast and easy suppply through the watering system.

  • Restrictions
  • Restrictions

    Do not apply to laying hens and young chickens less than 10 days before the beginning of oviposition due to the accumulation of levofloxacin in the egg, pregnant and lactating animals.

  • Publications
  • Publications
  • Treatment regimen

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