Levamisole 75

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Levamisole hydrochloride

Easy dosage due to the active substance content of 7.5%

Effective in the combat against all nematodes

Cost-effective


  • Description
  • A traditional levamisole-based drug intended for dehelminthization of animals in case of nematodes.

    Appearance: clear colorless liquid.

    Levamisole 75 is available as a sterile solution in 50 mL sealed glass vials with aluminum caps.


    Levamisole 75
  • Composition
  • Composition
    1 ml
    Levamisole

    75 mg levamisole

  • Pharmacological properties
  • Pharmacological properties

    Levamisole hydrochloride, the active substance of the drug, has a wide range of antinematodic activity, it is very effective against larva and mature forms of gastrointestinal and pulmonary nematodes including parasites of ruminants such as Haemonchus sp., Ostertagia sp., Trichostrongylus sp., Cooperia sp., Dictyocaulus sp., Protostrondylus sp., Nematodirus sp., Bunostomum sp., Oesophagostomum sp. and Chabertia sp.; parasites of pigs such as Ascaris suum, Strongyloides ransomi, Metastrongylus sp. and Oesophagostomum sp.; and parasites of dogs such as Toxocara sp., Toxascaris leonine, Uncinaria stenocephala and Ancylostoma caninum.
    The mechanism of action of this drug is as follows: Levamisole affects the neuromuscular system and inhibits the activity of parasitic agent’s enzymes, which eventually leads to its paralysis and death.
    After parenteral administration of the drug, levamisole hydrochloride is quickly resorbed from the injection site and distributed along the organs and tissues of the animal; concentration of levamisole hydrochloride reaches its peak value after 30-50 minutes and remains in the blood serum at a therapeutic level for 6-9 hours after the injection. Levamisole leaves the body unchanged within 3-7 days mostly with urine and partially with feces; in lactating animals, it can also partially be excreted in milk.
    Levamisole 75 belongs to moderately hazardous substances; if the recommended dose is maintained, the drug is well tolerated by animals and does not have any embrytoxic, teratogenic, mutagenic or sensitizing effect and does not cause local irritation.


  • Indications
  • Indications

    Levamisole 75 can be used as an antihelminthic drug to treat the following diseases:
    in cattle, sheep and goats: dictyocaulosis, haemonchosis, bunostomosis, oesophagostomiasis, nematodirosis, ostertagiosis, chabertiosis, cooperiosis, and strongyloidosis; in pigs: ascariasis, oesophagostomasis, strongyloidosis, trichocephalosis, chiostrongyloidosis and metastrongylosis;
    in dogs: toxocarosis, toxocaridosis, uncinariosis and ancylostomasis.

  • Dosage and route of administration
  • Dosage and route of administration

    Levamisole 75 can be used without prior starvation diet and application of laxatives, it shall be applied
    once subdermally (for bovine and small cattle it can be applied intramuscularly) with the dose being as follows: 1.0 ml per 10 kg of animal weight.
    Maximal dose of injected drug shall not exceed the following values:
    - for bovine cattle – 30 ml;
    - for pigs – 20 ml;
    - for sheep – 4,5 ml.
    Levamisole 75 has a very narrow range of therapeutic ratio, that’s why its dose shall be calculated with utmost precision.
    Before mass dehelminthization, each drug series is first tested on a small group of animals (5-10 subjects). If no complications are observed after 3 days, the rest of the herd shall be treated with this drug series.


  • Restrictions
  • Restrictions

    Slaughter of animals for meat is permitted not earlier than 7 days after the last treatment with Levamisole 75. Milk of dairy animals may not be used for human consumption within 3 days after the last administration.