Levamisole hydrochloride, the active substance of the drug, has a wide range of antinematodic activity, it is very effective against larva and mature forms of gastrointestinal and pulmonary nematodes including parasites of ruminants such as Haemonchus sp., Ostertagia sp., Trichostrongylus sp., Cooperia sp., Dictyocaulus sp., Protostrondylus sp., Nematodirus sp., Bunostomum sp., Oesophagostomum sp. and Chabertia sp.; parasites of pigs such as Ascaris suum, Strongyloides ransomi, Metastrongylus sp. and Oesophagostomum sp.; and parasites of dogs such as Toxocara sp., Toxascaris leonine, Uncinaria stenocephala and Ancylostoma caninum.
The mechanism of action of this drug is as follows: Levamisole affects the neuromuscular system and inhibits the activity of parasitic agent’s enzymes, which eventually leads to its paralysis and death.
After parenteral administration of the drug, levamisole hydrochloride is quickly resorbed from the injection site and distributed along the organs and tissues of the animal; concentration of levamisole hydrochloride reaches its peak value after 30-50 minutes and remains in the blood serum at a therapeutic level for 6-9 hours after the injection. Levamisole leaves the body unchanged within 3-7 days mostly with urine and partially with feces; in lactating animals, it can also partially be excreted in milk.
Levamisole 75 belongs to moderately hazardous substances; if the recommended dose is maintained, the drug is well tolerated by animals and does not have any embrytoxic, teratogenic, mutagenic or sensitizing effect and does not cause local irritation.