Levamisole 75

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Levamisole hydrochloride

A traditional levamisole-based drug intended for dehelminthization of animals in case of nematodes

Optimal content of the API

Effective against all nematodes


  • Description
  • A traditional levamisole-based drug intended for dehelminthization of animals in case of nematodes.

    Levamisole 75 is a clear colourless liquid. Packing: 50 mL sealed glass bottles with aluminum caps, filled with a sterile solution.

    Levamisole 75
  • Composition
  • Composition
    1 ml

    75 mg levamisole

  • Pharmacological properties
  • Pharmacological properties

    Levamisole hydrochloride has a broad spectrum of antinematodic activity; it is very effective against larvae and mature forms of gastrointestinal and pulmonary nematodes including parasites in ruminants such as Haemonchus spp., Ostertagia spp., Trichostrongylus spp., Cooperia spp., Dictyocaulus spp., Protostrongylus spp., Nematodirus spp., Bunostomum spp., Oesophagostomum spp., and Chabertia spp.; parasites in pigs such as Ascaris suum, Strongyloides ransomi, Metastrongylus spp. and Oesophagostomum spp.; and parasites in dogs such as Toxocara sp., Toxascaris leonine, Uncinaria stenocephala, and Ancylostoma caninum. Mode of action: levamisole affects the neuromuscular system and inhibits the activity of enzymes in parasitic agents, thus causing its paralysis and death. After parenteral administration of the drug, levamisole hydrochloride is quickly resorbed from the injection site and distributed along the organs and tissues of an animal; concentration of levamisole hydrochloride reaches its peak value in 30 to 50 minutes and remains in the blood serum at a therapeutic level for 6 to 9 hours after the injection. Levamisole is excreted from the body unchanged within 3 to 7 days, mostly with urine and partially with feces; in lactating animals, it can also partially be excreted with milk.

  • Indications
  • Indications

    Levamisole 75 is prescribed as an antihelminthic drug to treat the following diseases in cattle, sheep and goats: dictyocaulosis, haemonchosis, bunostomosis, oesophagostomiasis, nematodirosis, ostertagiosis, chabertiosis, cooperiosis, and strongyloidosis; in pigs: ascariasis, oesophagostomasis, strongyloidosis, trichocephalosis, chiostrongyloidosis, and metastrongylosis.

  • Dosage and route of administration
  • Dosage and route of administration

    Prior to use, Levamisole 75 does not require starvation diet and application of laxatives. It shall be applied once, subcutaneously (to cattle and small ruminants, it can be applied intramuscularly) at a dose of 1.0 mL of Levamisole 75 per 10 kg of animal body weight. To pigs it shall be applied once, subcutaneously at a dose of 1.0 mLof Levamisole 75 per 10 kg of animal body weight.

    Maximal dose of injected drug shall not exceed the following values:

    • in cattle - 30 mL

    • in sheep - 4.5 mL

    • in pigs - 20 mL


    Before mass deworming, each drug batch is first tested in a small group of animals (5 to 10 animals). If no complications occurred within 3 days, the drug is used throughout the livestock.


    Avoid using Levamisole 75 concurrently, within 10 days before, and 10 days after organophosphorus drugs, pyrantel, morantel, and chloramphenicol were administered. Avoid using the drug in animals suffering from contagious diseases, in recovering or debilitated animals, as well as in cows in the last third of gestation, ewes, goats, sows, and dogs in the second half of gestation.

  • Restrictions
  • Restrictions

    Treated animals can be slaughtered for human consumption no earlier than 7 days after the last application of Levamisole 75. In the case of forced slaughter of animals and poultry before the established deadlines, the meat can be used for feeding fur-bearing animals.

    Avoid using the milk, obtained from the treated milked animals, for human consumption within 3 days after applying Levamisole 75; once boiled, such milk may be used to feed animals.


    3 years from the date of manufacture, after first opening – 18 days