Broad-spectrum antimicrobial effect inherent to active iodine
No resistance of microorganisms
Abundant foam formation ensuring maximum contact of the active ingredient with the endometrium
No irritation for the uterine mucosa
Possible administration as a solution.
Intrauterine iodopovidone-based suppositories with a broad-spectrum antimicrobial action to prevent and treat postpartum endometritis.
Iodopen is hard brown cylindrical or pillow-like suppositories.
Packing: a blister with 2 suppositories.
1,5 g povidone iodine (1.57% of active iodine)
Iodopen has an antimicrobial, anti-inflammatory and anesthetic effect; it promotes proliferative processes occurring in genitals, moderately stimulates the tonus of the uterus, and decreases the recovery period. The active substance of the drug is an iodine organic compound (iodopovidone), which binds with protein in a microbial cell, thus blocking its respiratory enzymes.
Iodopen is prescribed to prevent and treat inflammatory processes that take place in the animal uterus as a result of obstructed or abnormal labour, which requires obstetric aid, surgical expulsion of afterbirth, abortions or acute postpartum endometritis.
| Microbiological efficacy of povidone iodine (0.1% active iodine concentration) | |||
| Species | Time of death (seconds) | Microbe strain | Time of death Microbe strain (seconds) |
| Staphilococcus aureus | 15-30 | Pseudomonas aeruginosa | 15-30 |
| Proteus vulgares | 60-90 | Diplococcus pneumoniae | 60 |
| Enterobacter spp. | 60 | Bacillus subtilis | 30 |
| Steptococcus faecalis | 60 | Clostridium septicum | 30 |
| Streptococcus pyogenes | 60 | Escherichia coli | 30-60 |
| Streptococcus hemolyticus | 15 | ||
| Salmonella typhimurium | 30 | ||
As a preventative measure, one suppository is administered once following afterbirth, abortion, or aided labour; as a treatment measure - one suppository, twice, with a 24- to 48-hour interval. In special cases, the treatment is continued until the animal is fully recovered. Suppositories are introduced into uterine cavity by hand (protected by polyethylene disposable glove). Before application of Iodopen, vulva and tailhead have to be cleansed first.
Due to the foaming basis of the drug, after administration of one suppository, at least 300 mL of foam is formed to ensure the maximum contact of the active ingredient with the endometrium.
When the cervix is closed and it is impossible to introduce the drug in the form of a suppository, it is recommended to use a solution. To prepare the solution, one Iodopen suppository is dissolved in 150 to 200 mL of preheated to 40 °C sterile saline or water. Destruction of the foam is done mechanically or by using defoamers (ethyl alcohol). The resulting solution is introduced into a Janet's syringe or Esmarch's irrigator. The solution shall be administered slowly intrauterinally, using a catheter for artificial insemination or using a 20 to 25 cm silicone tube 0.5 cm in diameter, equipped with a polystyrene pipette. The treatment is carried out once a day, until recovery.
In order to increase the contractive activity of the uterus and accelerate evacuation of exudate, Iodopen is recommended to be used with Uteroton. Uteroton is administered intramuscularly, 5 mL per animal immediately after the first administration of Iodopen.
The drug shall be stored in a dry place, at a temperature of 4 to 20°C.
The milk, obtained from the treated milked animals, may be used for human consumption not earlier than 24 hours after the last administration of the drug. The milk, obtained from milked cows during treatment and within 24 hours after the last injection was made, may be used for feeding animals after boiling.
No restrictions set for meat used for human consumption.
Intolerance and hypersensitivity of an animal to iodine and/or drug components, or hyperthyroidism. Avoid using the drug concurrently with other intra-uterine drugs.
18 months from the date of manufacture; the product should not be stored after opening the blister strip.
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