Florydox

Always helps

Florfenicol, doxycycline

An original broad-spectrum antibacterial drug

Active against most Gram-positive and Gram-negative bacteria

No resistance development due to florfenicol and doxycycline combination

Proven over 97% therapeutic efficacy

Description
A complex new generation antibacterial drug for treatment of calves, sheep and pigs, with a wide range of action, comprising doxycycline improved by florfenicol. Administration of florydox requires no titration.
Appearance: a clear brown to dark brown liquid.
Florydox is packaged in 50 mL dark glass vials.
Composition
Composition

1 ml
Florydox

50 mg doxycycline

100 mg florfenicol
Pharmacological properties
Pharmacological properties

Florydox is a complex antibacterial drug. It consists of two antibiotics, doxycycline hydrochloride and florfenicol, ensuring its high efficiency against a wide range of Gram-positive and Gram-negative bacteria.
Doxycycline is a semisynthetic tetracycline group antibiotic and is effective against Gram-positive and Gram-negative microbes including Escherichia coli., Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, Haemophilus spp., Pasteurella spp., Salmonella spp., Staphylococcus spp., Streptococcus spp., Leptospira spp., Chlamydia spp, Clostridium perfringens, Listeria monocytogenes, Corynebacterium pyogenes, Rickettsiae spp. The mechanism of bacterial growth-inhibition activity of doxycycline involves the disruption of protein synthesis inside the microbial cell ribosomes.
Florfenicol is a phenicol group antibiotic and is a thiamphenicol derivative where hydroxyl group is substituted with fluorine. Florfenicol has a wide range of antibacterial activity against Staphylococcus spp., Streptococcus spp., Escherichia coli, Actinobacillus pleuropneumoniae, Pasteurella spp., Bordetella bronchiseptica, Haemophilus spp., Fusobacterium necrophorum, Klebsiella pneumoniae as well as acetyl transferase producing bacteria resistant to chloramphenicol. Florfenicol has bacteriostatic activity: it binds with the 70S ribosomal subunit of bacterial cell protoplasm, thus blocking peptidyl transferase that leads to the inhibition of protein synthesis by ribosomes of sensitive microbial cells.
After intramuscular injection of Florydox, its active substances are quickly absorbed from the injection site and distributed among the organs and tissues of the animal. Florydox concentration in organs and tissues remains at its therapeutic level for 24 hours after administration of the drug. Doxycycline is scarcely metabolized; florfenicol is metabolized in the liver and is eliminated mostly with bile and urine, and partially with feces.
Indications

Indications

Florydox is indicated for therapeutic purposes for calves, small cattle and pigs against respiratory and gastrointestinal diseases caused by bacteria sensitive to florfenicol and doxycycline.

High efficacy of Florydox in treatment of diseases of bacterial etiology

Disease	Duration of treatment	Therapeutic efficacy
Salmonellosis of piglets	3 days	100%
Colibacteriosis of piglets	3 days	99%
Bronchopneumonia of calves and pigs	3 days	97%
Bronchopneumonia of lambs	3 days	100%
Colibacteriosis of lambs	3 days	100%

The results of the therapeutic efficacy research of Florydox have shown 100% efficacy in Salmonellosis of piglets, 99% - in Colibacteriosis of piglets and lambs and 97% in Bronchopneumonia of calves, lambs and pigs.

Dosage and route of administration
Dosage and route of administration

Florydox is injected intramuscularly once for 3-5 consecutive days with the doze being as follows:

- for calves – 1.0 ml per 7.5 kg of animal weight;

- for pigs - 1.0 ml per 10.0 kg of animal weight.

If the required volume of the drug exceeds 2.5 ml for piglets and 5 ml for pigs and calves, several injections in various places shall be administered in order to avoid a possible painful reaction. The drug shall not be mixed with other drugs in one syringe. The drug shall be applied regularly as any disruption of the application order may lead to decreasement of the drug’s therapeutic efficacy. If another application of the drug has been omitted, the next application shall be done as soon as possible, with the term of application remaining the same as before.
Restrictions
Restrictions

Treated pigs can be slaughtered for food no sooner than 34 days after the last application of Florydox; treated calves can be slaughtered for food no sooner than 40 days after the last application of Florydox. In case of compulsory slaughter occurring before the above stated period, the meat of slaughtered animals may be used as a fur animal feed.

Description
Composition
Pharmacological properties
Indications
Dosage and route of administration
Restrictions

A complex new generation antibacterial drug for treatment of calves, sheep and pigs, with a wide range of action, comprising doxycycline improved by florfenicol. Administration of florydox requires no titration.
Appearance: a clear brown to dark brown liquid.
Florydox is packaged in 50 mL dark glass vials.

Composition

1 ml

Florydox

50 mg doxycycline

100 mg florfenicol

Pharmacological properties

Florydox is a complex antibacterial drug. It consists of two antibiotics, doxycycline hydrochloride and florfenicol, ensuring its high efficiency against a wide range of Gram-positive and Gram-negative bacteria.
Doxycycline is a semisynthetic tetracycline group antibiotic and is effective against Gram-positive and Gram-negative microbes including Escherichia coli., Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, Haemophilus spp., Pasteurella spp., Salmonella spp., Staphylococcus spp., Streptococcus spp., Leptospira spp., Chlamydia spp, Clostridium perfringens, Listeria monocytogenes, Corynebacterium pyogenes, Rickettsiae spp. The mechanism of bacterial growth-inhibition activity of doxycycline involves the disruption of protein synthesis inside the microbial cell ribosomes.
Florfenicol is a phenicol group antibiotic and is a thiamphenicol derivative where hydroxyl group is substituted with fluorine. Florfenicol has a wide range of antibacterial activity against Staphylococcus spp., Streptococcus spp., Escherichia coli, Actinobacillus pleuropneumoniae, Pasteurella spp., Bordetella bronchiseptica, Haemophilus spp., Fusobacterium necrophorum, Klebsiella pneumoniae as well as acetyl transferase producing bacteria resistant to chloramphenicol. Florfenicol has bacteriostatic activity: it binds with the 70S ribosomal subunit of bacterial cell protoplasm, thus blocking peptidyl transferase that leads to the inhibition of protein synthesis by ribosomes of sensitive microbial cells.
After intramuscular injection of Florydox, its active substances are quickly absorbed from the injection site and distributed among the organs and tissues of the animal. Florydox concentration in organs and tissues remains at its therapeutic level for 24 hours after administration of the drug. Doxycycline is scarcely metabolized; florfenicol is metabolized in the liver and is eliminated mostly with bile and urine, and partially with feces.

Indications

Florydox is indicated for therapeutic purposes for calves, small cattle and pigs against respiratory and gastrointestinal diseases caused by bacteria sensitive to florfenicol and doxycycline.

High efficacy of Florydox in treatment of diseases of bacterial etiology

Disease	Duration of treatment	Therapeutic efficacy
Salmonellosis of piglets	3 days	100%
Colibacteriosis of piglets	3 days	99%
Bronchopneumonia of calves and pigs	3 days	97%
Bronchopneumonia of lambs	3 days	100%
Colibacteriosis of lambs	3 days	100%

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Dosage and route of administration

Florydox is injected intramuscularly once for 3-5 consecutive days with the doze being as follows:

- for calves – 1.0 ml per 7.5 kg of animal weight;

- for pigs - 1.0 ml per 10.0 kg of animal weight.

If the required volume of the drug exceeds 2.5 ml for piglets and 5 ml for pigs and calves, several injections in various places shall be administered in order to avoid a possible painful reaction. The drug shall not be mixed with other drugs in one syringe. The drug shall be applied regularly as any disruption of the application order may lead to decreasement of the drug’s therapeutic efficacy. If another application of the drug has been omitted, the next application shall be done as soon as possible, with the term of application remaining the same as before.

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Restrictions

Treated pigs can be slaughtered for food no sooner than 34 days after the last application of Florydox; treated calves can be slaughtered for food no sooner than 40 days after the last application of Florydox. In case of compulsory slaughter occurring before the above stated period, the meat of slaughtered animals may be used as a fur animal feed.

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