Florydox is a complex antibacterial drug. It consists of two antibiotics, doxycycline hydrochloride and florfenicol, ensuring its high efficiency against a wide range of Gram-positive and Gram-negative bacteria.
Doxycycline is a semisynthetic tetracycline group antibiotic and is effective against Gram-positive and Gram-negative microbes including Escherichia coli., Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, Haemophilus spp., Pasteurella spp., Salmonella spp., Staphylococcus spp., Streptococcus spp., Leptospira spp., Chlamydia spp, Clostridium perfringens, Listeria monocytogenes, Corynebacterium pyogenes, Rickettsiae spp. The mechanism of bacterial growth-inhibition activity of doxycycline involves the disruption of protein synthesis inside the microbial cell ribosomes.
Florfenicol is a phenicol group antibiotic and is a thiamphenicol derivative where hydroxyl group is substituted with fluorine. Florfenicol has a wide range of antibacterial activity against Staphylococcus spp., Streptococcus spp., Escherichia coli, Actinobacillus pleuropneumoniae, Pasteurella spp., Bordetella bronchiseptica, Haemophilus spp., Fusobacterium necrophorum, Klebsiella pneumoniae as well as acetyl transferase producing bacteria resistant to chloramphenicol. Florfenicol has bacteriostatic activity: it binds with the 70S ribosomal subunit of bacterial cell protoplasm, thus blocking peptidyl transferase that leads to the inhibition of protein synthesis by ribosomes of sensitive microbial cells.
After intramuscular injection of Florydox, its active substances are quickly absorbed from the injection site and distributed among the organs and tissues of the animal. Florydox concentration in organs and tissues remains at its therapeutic level for 24 hours after administration of the drug. Doxycycline is scarcely metabolized; florfenicol is metabolized in the liver and is eliminated mostly with bile and urine, and partially with feces.