Florox

When others are powerless
Cattle
Swine
Florfenicol

Professional antibacterial drug

Florfenicol is designed specifically for veterinary medicine

Reduces the losses of young animals and maintains weight gain due to the quick effect of the drug

Increased bioavailability

  • Description
  • One of the most affordable professional antimicrobial florfenicol-based drugs at the RF and CIS markets with a prolonged action against respiratory diseases of calves and piglets.
    Appearance: transparent  from brown to dark brown liquid.
    Available as a sterile solution filled in 100 mL glass vials.

    Florox
  • Composition
  • Composition

    1 ml Florox = 300 mg florfenicol

  • Pharmacological properties
  • Pharmacological properties

    Florfenicol, the active substance of Florox, is a thiamphenicol derivative where the hydroxyl group is substituted with fluorine. Florfenicol has a bacteriostatic activity: it binds with the 70S ribosomal subunit in the bacterial cell protoplasm, thus blocking peptidyl transferase, which leads to the inhibition of protein synthesis performed by ribosomes of the sensitive microbial cell. Florfenicol is effective against acetyl transferase-producing bacteria resistant to chloramphenicol. Florfenicol has a wide range of antibacterial activity against Staphylococcus spp., Streptococcus spp., Escherichia coli, Actinobacillus pleuropneumoniae, Pasteurella spp., Bordetella bronchiseptica, Haemophilus spp., Fusobacterium necrophorum, Klebsiella pneumoniae, as well as mycoplasma M. hyopneumoniae и M. hyorhinis. After parenteral administration, florfenicol is quickly absorbed and distributed among most organs and tissues of the animal. It reaches its peak serum concentration after 30-90 minutes and remains at the therapeutic level for at least 48 hours. Florfenicol is eliminated unchanged as metabolites mostly with urine and partially with feces.


  • Indications
  • Indications

    Florox is indicated for pigs and cattle to treat bacterial diseases the etiological agents of which are sensitive to florflenicol.
    In pigs: respiratory diseases including pleuropneumonia (caused by Actinobacillus pleuropneumoniae and/or Haemophilus parasuis, Pasteurella multоcida, M. hyopneumoniae, M. hyorhinis) and atrophic rhinitis.
    In cattle: respiratory diseases (caused by Pasteurella multicida, Klebsiella pneumoniae, Streptococcus pneumoniae, Haemophilus somnus), necrobacillosis, contagious keratoconjunctivitis (caused by Moraxella bovis).




  • Dosage and route of administration
  • Dosage and route of administration

    In pigs, 1 mL per 20 kg of animal weight (15 mg of florflenicol per 1 kg) shall be administered intramuscularly in the neck area twice with 48 hours interval .
    In cattle, 1 mL per 15 kg of animal weight (20 mg of florflenicol per 1 kg) shall be administered intramuscularly twice with 48 hours interval or 2 mL per 15 kg of animal weight (40 mg of florflenicol per 1 kg) once subcutaneously .


  • Restrictions
  • Restrictions

    Treated pigs may be slaughtered for food no sooner than 14 days after injection of Florox. Treated cattle may be slaughtered for food no sooner than 34 days after the intramuscular injection and 42 days after the subdermal injection of Florox. In case of compulsory slaughter occurring before the above stated period, the meat of slaughtered animals may be used as feed for fur animals.

  • Publications
  • Publications
  • Treatment regimen

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