Florox OR

Pure effectiveness

Swine

Poultry

Florfenicol

Antimicrobial florfenicol-based solution highly-effective in treatment of respiratory and gastrointestinal diseases in poultry and swine

No clogged drinking pans *

Its action starts in 10 minutes

Highly-effective in pasteurellosis, colibacillosis, salmonellosis of poultry and in pleuropneumonia and atrophic rhinitis in piglets

*Feeding without preliminanry preparation of stock solution (concentrate) using a dispenser unit

Description
Antimicrobial florfenicol-based solution highly-effective in treatment of respiratory and gastrointestinal diseases in poultry and swine.

Appearance: transparent slightly viscous brown light-yellow to dark yellow solution.

The drug is available in 1 L polymer bottles.
Composition
Composition
Pharmacological properties
Pharmacological properties

Florfenicol, an active ingredient of the drug, is a derivative of thiamphenicol where hydroxyl group is substituted with fluorine. It has bacteriostatic activity: it binds with ribosomal subunit 705 of bacterial cell protoplasm, thus blocking peptidyl transferase which leads to inhibition of protein synthesis performed by ribosomes of sensitive microbial cell.

It is effective against bacteria producing acetyl transferase which are resistant to chloramphenicol.

Florfenicol has a wide range of antibacterial activity against Streptococcus spp., Salmonella spp., Escherichia coli, Proteus spp., Staphylococcus aureus., Actinobacillus pleuropneumoniae, Pasteurella multocida. Pasteurell haemolytica, Bordetella bronchiseptica, Haemophilus spp., Klebciella spp., Ornithobacterium rhinotracheale, Mycoplasma hyopneumoniae. Mycoplasma hyorhinis. Florfenicol is effective against bacteria producing acetyl transferase which are resistant to chloramphenicol.

After oral administration, florfenicol is well absorbed from GI tract and gets into most organs and tissues but does not penetrate through blood-tissue barriers. Bioavailability of florfenicol after oral administration is 88% in pigs and 55% in poultry. The antibiotic reaches its peak serum concentration after 1 hour and remains at the therapeutic level for at least 24 hours. The antibiotic and its metabolites are eliminated from the body of poultry mostly with litter, in egg-laying poultry - also with eggs, from the body of pigs - mostly with urine and less with feces.
Indications
Indications

Swine: Florox OR is used to treat bacterial respiratory diseases in pleuropneumonia caused by Actinobacillus pleuropneumoniae, Haemophilus parasuis, in atrophic rhinitis caused by Pasteurella multocida, Bordetella bronchiseptica, mycoplasma infections as well as with other bacterial diseases induced by the microbial agents sensitive to florfenicol.

Poultry: Florox OR is used in case of pasteurellosis, staphylococcus, salmonellosis, mycoplasmosis, hemophilia, respiratory diseases including those caused by Ornithobacterium rhinotracheale, and other infectious diseases induced by the microbial agents sensitive to florfenicol. The drug is used in treatment of secondary infections in viral diseases (including colibacteriosis).
Dosage and route of administration
Dosage and route of administration

Florox OR is administered orally to individual animals or groups of animals with drinking water:

Swine: daily dose 5mg of florfenicol per 1 kg of animal weight ( corresponds to 5 ml of the drug per 100 kg of animal weight) daily for 7 days.

Poultry: daily dose 20 mg of florfenicol per 1 kg of weight (or 0.2 ml of the drug per 1 kg of weight), which corresponds to: in chickens up to 4 weeks – 100 ml of the drug per 100 l of water (1 ml per 1 l); in poultry of other age categories – 200 ml of the drug per 100 l of water (2 ml per 1 l), daily for 3 days, in salmonellosis for 5 days.

During the treatment period, animals and poultry shall only drink water that contains the drug. If it is impossible then the daily dose should be divided into 2 parts and given at 12-hour interval.
Restrictions
Restrictions

Swine may be slaughtered for food no sooner than 12 days, poultry - 5 days after the last drug administration. The meat of the animals slaughtered before the above stated period can be used as carnivore feed.
Publications
Publications
Treatment regimen

Description
Composition
Pharmacological properties
Indications
Dosage and route of administration
Restrictions

Antimicrobial florfenicol-based solution highly-effective in treatment of respiratory and gastrointestinal diseases in poultry and swine.

Appearance: transparent slightly viscous brown light-yellow to dark yellow solution.

The drug is available in 1 L polymer bottles.

Composition

Pharmacological properties

Florfenicol, an active ingredient of the drug, is a derivative of thiamphenicol where hydroxyl group is substituted with fluorine. It has bacteriostatic activity: it binds with ribosomal subunit 705 of bacterial cell protoplasm, thus blocking peptidyl transferase which leads to inhibition of protein synthesis performed by ribosomes of sensitive microbial cell.

It is effective against bacteria producing acetyl transferase which are resistant to chloramphenicol.

Florfenicol has a wide range of antibacterial activity against Streptococcus spp., Salmonella spp., Escherichia coli, Proteus spp., Staphylococcus aureus., Actinobacillus pleuropneumoniae, Pasteurella multocida. Pasteurell haemolytica, Bordetella bronchiseptica, Haemophilus spp., Klebciella spp., Ornithobacterium rhinotracheale, Mycoplasma hyopneumoniae. Mycoplasma hyorhinis. Florfenicol is effective against bacteria producing acetyl transferase which are resistant to chloramphenicol.

After oral administration, florfenicol is well absorbed from GI tract and gets into most organs and tissues but does not penetrate through blood-tissue barriers. Bioavailability of florfenicol after oral administration is 88% in pigs and 55% in poultry. The antibiotic reaches its peak serum concentration after 1 hour and remains at the therapeutic level for at least 24 hours. The antibiotic and its metabolites are eliminated from the body of poultry mostly with litter, in egg-laying poultry - also with eggs, from the body of pigs - mostly with urine and less with feces.

Indications

Swine: Florox OR is used to treat bacterial respiratory diseases in pleuropneumonia caused by Actinobacillus pleuropneumoniae, Haemophilus parasuis, in atrophic rhinitis caused by Pasteurella multocida, Bordetella bronchiseptica, mycoplasma infections as well as with other bacterial diseases induced by the microbial agents sensitive to florfenicol.

Poultry: Florox OR is used in case of pasteurellosis, staphylococcus, salmonellosis, mycoplasmosis, hemophilia, respiratory diseases including those caused by Ornithobacterium rhinotracheale, and other infectious diseases induced by the microbial agents sensitive to florfenicol. The drug is used in treatment of secondary infections in viral diseases (including colibacteriosis).

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Dosage and route of administration

Florox OR is administered orally to individual animals or groups of animals with drinking water:

Swine: daily dose 5mg of florfenicol per 1 kg of animal weight ( corresponds to 5 ml of the drug per 100 kg of animal weight) daily for 7 days.

Poultry: daily dose 20 mg of florfenicol per 1 kg of weight (or 0.2 ml of the drug per 1 kg of weight), which corresponds to: in chickens up to 4 weeks – 100 ml of the drug per 100 l of water (1 ml per 1 l); in poultry of other age categories – 200 ml of the drug per 100 l of water (2 ml per 1 l), daily for 3 days, in salmonellosis for 5 days.

During the treatment period, animals and poultry shall only drink water that contains the drug. If it is impossible then the daily dose should be divided into 2 parts and given at 12-hour interval.

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Restrictions

Swine may be slaughtered for food no sooner than 12 days, poultry - 5 days after the last drug administration. The meat of the animals slaughtered before the above stated period can be used as carnivore feed.

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