Florox OR

Pure effectiveness
Свиньи - изображение NITA FARM
Птица - изображение NITA FARM
Florox ORPhoto1
Florfenicol

An antimicrobial florfenicol-based solution, highly effective in treating respiratory and gastrointestinal diseases in pigs and poultry.

Does not block drinkers1

Action starts in 10 minutes

Highly effective in treating pasteurellosis, colibacillosis, and salmonellosis in poultry, and pleuropneumonia and atrophic rhinitis in piglets2.







1 - Feeding without preliminary preparation of a stock solution (concentrate) using a dispenser unit
2 - Studies on the therapeutic efficacy of Florox OR were carried out at OZOS MNIC, LLC, in piglets, chicks, and young animals of various age categories (2017)
  • Description
  • An antimicrobial florfenicol-based solution, highly effective in treating respiratory and gastrointestinal diseases in pigs and poultry.

    Florox OR is a transparent slightly viscous light yellow to dark yellow solution.

    Packing: 1000 mL plastic bottles, 5L polymer canisters.

    Florox OR
  • Composition
  • Composition
    1 ml
    Florox OR

    100 mg florfenicol

  • Pharmacological properties
  • Pharmacological properties

    Florfenicol has a broad-spectrum antibacterial activity against Streptococcus spp., Salmonella spp., Escherichia coli, Proteus spp., Staphylococcus aureus, Actinobacillus pleuropneumoniae, Pasteurella multocida, Pasteurella haemolytica, Bordetella bronchiseptica, Haemophilus spp., Klebsiella spp., Ornithobacterium rhinotracheale, Mycoplasma hyopneumoniae, and Mycoplasma hyorhinis. Florfenicol is effective against acetyl transferase-producing bacteria, which are resistant to chloramphenicol. Florfenicol is a derivative of thiamphenicol, where a hydroxyl group is substituted with fluorine. Florfenicol has a bacteriostatic effect: it binds with the 70S ribosomal subunit in the bacterial cell protoplasm, thus blocking peptidyl transferase, which leads to the inhibition of protein synthesis in ribosomes of the sensitive microbial cell.

    Administered orally, florfenicol is well absorbed from the GI tract and gets into most organs and tissues, but does not penetrate through blood-tissue barriers. Bioavailability of florfenicol after oral administration is 88% in pigs and 55% in poultry. The antibiotic reaches its peak serum concentration in 1 hour and remains at the therapeutic level for at least 24 hours. The antibiotic and its metabolites are eliminated from the body of pigs mostly with urine and, to a lesser extent, with feces. 

  • Indications
  • Indications

    Swine

    INDICATIONS 

    • Bacterial respiratory diseases, incl. pleuropneumonia, caused by Actinobacillus pleuropneumoniae, Haemophilus parasuis

    • Atrophic rhinitis caused by Pasteurella multocida, Bordetella bronchiseptica

    • Mycoplasma infections caused by M. hyopneumoniae, M. hyorhinis

    • Other bacterial diseases induced by the microbial florfenicol-sensitive agents

    DOSAGE AND ADMINISTRATION

    • Orally 5 mL of the drug/100 kg of animal body weight or 5 mg of florfenicol/1 kg of animal body weight for 7 days 


    Florfenicol may precipitate, if its concentration exceeds 10 mL per 1 L of water.

    Efficacy in treating respiratory diseases in pigs with Florox OR

    Florox OR is highly effective in treating pleuropneumonia caused by Actinobacillus pleuropneumoniae, Haemophilus parasuis, and atrophic rhinitis caused by Pasteurella multocida, and Bordetella bronchiseptica.


    Administered orally, florfenicol is well absorbed from the GI tract and gets into most organs and tissues, but does not penetrate through blood-tissue barriers. Bioavailability of florfenicol after oral administration is 88% in pigs and 55% in poultry. The antibiotic reaches its peak serum concentration in 1 hour and remains at the therapeutic level for at least 24 hours. The antibiotic and its metabolites are eliminated from the body of pigs mostly with urine and, to a lesser extent, with feces; from poultry - mostly with feces; and from egglaying poultry - also with eggs.

    Poultry

    INDICATIONS

    • Pasteurellosis, staphylococcus, salmonellosis, mycoplasmosis, hemophilia, and respiratory diseases including those caused by Ornithobacterium rhinotracheale
    • Secondary infections in viral diseases (including colibacteriosis)
    • Other infectious diseases induced by the microbial florfenicol-sensitive agents

    DOSAGE AND ADMINISTRATION

    Orally for 3 days; in the case of salmonellosis - 0,2 mL of the drug/1 kg of animal body weight or 20 mg of florfenicol/1 kg of animal body weight for 5 days

    • chicks under the age of 4 weeks – 100 mL of the drug/100 L of water (1 mL per 1 L)

    • poultry of other age categories – 200 mL of the drug/100 L of water (2 mL per 1 L)

    Florfenicol may precipitate, if its concentration exceeds 10 mL per 1 L of water


  • Dosage and route of administration
  • Dosage and route of administration

    Swine

    INDICATIONS 

    • Bacterial respiratory diseases, incl. pleuropneumonia, caused by Actinobacillus pleuropneumoniae, Haemophilus parasuis

    • Atrophic rhinitis caused by Pasteurella multocida, Bordetella bronchiseptica

    • Mycoplasma infections caused by M. hyopneumoniae, M. hyorhinis

    • Other bacterial diseases induced by the microbial florfenicol-sensitive agents

    DOSAGE AND ADMINISTRATION

    • Orally 5 mL of the drug/100 kg of animal body weight or 5 mg of florfenicol/1 kg of animal body weight for 7 days 


    Florfenicol may precipitate, if its concentration exceeds 10 mL per 1 L of water.

    Efficacy in treating respiratory diseases in pigs with Florox OR

    Florox OR is highly effective in treating pleuropneumonia caused by Actinobacillus pleuropneumoniae, Haemophilus parasuis, and atrophic rhinitis caused by Pasteurella multocida, and Bordetella bronchiseptica.


    Administered orally, florfenicol is well absorbed from the GI tract and gets into most organs and tissues, but does not penetrate through blood-tissue barriers. Bioavailability of florfenicol after oral administration is 88% in pigs and 55% in poultry. The antibiotic reaches its peak serum concentration in 1 hour and remains at the therapeutic level for at least 24 hours. The antibiotic and its metabolites are eliminated from the body of pigs mostly with urine and, to a lesser extent, with feces; from poultry - mostly with feces; and from egglaying poultry - also with eggs.

    Poultry

    INDICATIONS

    • Pasteurellosis, staphylococcus, salmonellosis, mycoplasmosis, hemophilia, and respiratory diseases including those caused by Ornithobacterium rhinotracheale
    • Secondary infections in viral diseases (including colibacteriosis)
    • Other infectious diseases induced by the microbial florfenicol-sensitive agents

    DOSAGE AND ADMINISTRATION

    Orally for 3 days; in the case of salmonellosis - 0,2 mL of the drug/1 kg of animal body weight or 20 mg of florfenicol/1 kg of animal body weight for 5 days

    • chicks under the age of 4 weeks – 100 mL of the drug/100 L of water (1 mL per 1 L)

    • poultry of other age categories – 200 mL of the drug/100 L of water (2 mL per 1 L)

    Florfenicol may precipitate, if its concentration exceeds 10 mL per 1 L of water


  • Restrictions
  • Restrictions

    CONTRAINDICATIONS

    Hypersensitivity of an animal to the drug components (the history of it).

    RESTRICTIONS

    Pigs may be slaughtered for human consumption no earlier than 15 days, poultry - no earlier than 6 days after the drug was administered for the last time. In the case of forced slaughter of animals before the established deadlines, the meat can be used for feeding carnivores.

    SHELF LIFE

    2 years from the date of manufacture; after first opening - 28 days.

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