Florox OR

Florfenicol has a broad-spectrum antibacterial activity against Streptococcus spp., Salmonella spp., Escherichia coli, Proteus spp., Staphylococcus aureus, Actinobacillus pleuropneumoniae, Pasteurella multocida, Pasteurella haemolytica, Bordetella bronchiseptica, Haemophilus spp., Klebsiella spp., Ornithobacterium rhinotracheale, Mycoplasma hyopneumoniae, and Mycoplasma hyorhinis. Florfenicol is effective against acetyl transferase-producing bacteria, which are resistant to chloramphenicol. Florfenicol is a derivative of thiamphenicol, where a hydroxyl group is substituted with fluorine. Florfenicol has a bacteriostatic effect: it binds with the 70S ribosomal subunit in the bacterial cell protoplasm, thus blocking peptidyl transferase, which leads to the inhibition of protein synthesis in ribosomes of the sensitive microbial cell.

Administered orally, florfenicol is well absorbed from the GI tract and gets into most organs and tissues, but does not penetrate through blood-tissue barriers. Bioavailability of florfenicol after oral administration is 88% in pigs and 55% in poultry. The antibiotic reaches its peak serum concentration in 1 hour and remains at the therapeutic level for at least 24 hours. The antibiotic and its metabolites are eliminated from the body of pigs mostly with urine and, to a lesser extent, with feces. 

Swine

INDICATIONS 

• Bacterial respiratory diseases, incl. pleuropneumonia, caused by Actinobacillus pleuropneumoniae, Haemophilus parasuis

• Atrophic rhinitis caused by Pasteurella multocida, Bordetella bronchiseptica

• Mycoplasma infections caused by M. hyopneumoniae, M. hyorhinis

• Other bacterial diseases induced by the microbial florfenicol-sensitive agents

DOSAGE AND ADMINISTRATION

• Orally 5 mL of the drug/100 kg of animal body weight or 5 mg of florfenicol/1 kg of animal body weight for 7 days 

Florfenicol may precipitate, if its concentration exceeds 10 mL per 1 L of water.

Efficacy in treating respiratory diseases in pigs with Florox OR

Florox OR is highly effective in treating pleuropneumonia caused by Actinobacillus pleuropneumoniae, Haemophilus parasuis, and atrophic rhinitis caused by Pasteurella multocida, and Bordetella bronchiseptica.

Administered orally, florfenicol is well absorbed from the GI tract and gets into most organs and tissues, but does not penetrate through blood-tissue barriers. Bioavailability of florfenicol after oral administration is 88% in pigs and 55% in poultry. The antibiotic reaches its peak serum concentration in 1 hour and remains at the therapeutic level for at least 24 hours. The antibiotic and its metabolites are eliminated from the body of pigs mostly with urine and, to a lesser extent, with feces; from poultry - mostly with feces; and from egglaying poultry - also with eggs.

Poultry

INDICATIONS

• Pasteurellosis, staphylococcus, salmonellosis, mycoplasmosis, hemophilia, and respiratory diseases including those caused by Ornithobacterium rhinotracheale
• Secondary infections in viral diseases (including colibacteriosis)
• Other infectious diseases induced by the microbial florfenicol-sensitive agents

DOSAGE AND ADMINISTRATION

Orally for 3 days; in the case of salmonellosis - 0,2 mL of the drug/1 kg of animal body weight or 20 mg of florfenicol/1 kg of animal body weight for 5 days

• chicks under the age of 4 weeks – 100 mL of the drug/100 L of water (1 mL per 1 L)

• poultry of other age categories – 200 mL of the drug/100 L of water (2 mL per 1 L)

Florfenicol may precipitate, if its concentration exceeds 10 mL per 1 L of water

CONTRAINDICATIONS

Hypersensitivity of an animal to the drug components (the history of it).

RESTRICTIONS

Pigs may be slaughtered for human consumption no earlier than 15 days, poultry - no earlier than 6 days after the drug was administered for the last time. In the case of forced slaughter of animals before the established deadlines, the meat can be used for feeding carnivores.

SHELF LIFE

2 years from the date of manufacture; after first opening - 28 days.