Enronit

From the one impact
Cattle
Small cattle
Swine
In one blow

A complex drug with high efficiency against colibacillosis

More efficient than enrofloxacin-based monodrugs with comparable cost of treatment

Slow development of microorganisms’ resistance compared to enrofloxacin-based monodrugs allows using the drug for a long time

High efficiency against colibacillosis - 91.4%

The components of the drug have a synergistic effect

  • Description
  • A complex drug with high efficiency against colibacillosis and slow development of microorganisms’ resistance due to the synergistic effect of enrofloxacin and colistin, unlike monodrugs.

    Appearance: a transparent or opalescent  to yellow liquid.

    Enronit is manufactured in 50 and 100 mL sealed glass vials



    Enronit
  • Composition
  • Composition
    1 ml Enronit = 50 mg enrofloxacin, 500 000 IU colistin
  • Pharmacological properties
  • Pharmacological properties

    A synergistic combination of enrofloxacin and colistin sulfate, the active substances of Enronit, enhance each other’s effects, thus providing a wide range of antimicrobial activity against Gram-positive and Gram-negative microbes. The mechanism of action of enrofloxacin is as follows: enrofloxacin inhibits the activity of gyrase (an enzyme that affects the replication of DNA spiral in the nucleus of the bacterial cell), which allows it to disrupt the protein synthesis and suppress the growth and development of Gram-positive and Gram-negative bacteria including Escherichia coli, Haemophilus spp., Pasteurella spp., Salmonella spp., Staphylococcus spp., Streptococcus spp., Clostridium perfringens, Bordetella spp., Campylobacter spp., Corynebacterium pyogenes, Pseudomonas aeruginosa. and Mycoplasma spp. Colistin sulfate impairs the permeability of the bacterial cell walls by connecting to lypoproteins that leads to a change in the intracellular metabolism and causes death of Gram-negative bacteria including Escherichia coli, Pseudomonas aeruginosa, Klebsiella spp, Salmonella spp. and Proteus spp.
    After injection, Enronit is quickly resorbed from the injection site and distributed among the organs and tissues of the animal. Concentration of enrofloxacin in blood serum reaches its peak value after 1-2 hours, while concentration of colistin sulfate in blood serum reaches its peak value after 1 hour. Enrofloxacin and colistin sulfate are eliminated unchanged mostly with feces and partially with urine.



  • Indications
  • Indications

    A synergistic combination of enrofloxacin and colistin sulfate, the active substances of Enronit, enhance each other’s effects, thus providing a wide range of antimicrobial activity against Gram-positive and Gram-negative microbes. The mechanism of action of enrofloxacin is as follows: enrofloxacin inhibits the activity of gyrase (an enzyme that affects the replication of DNA spiral in the nucleus of the bacterial cell), which allows it to disrupt the protein synthesis and suppress the growth and development of Gram-positive and Gram-negative bacteria including Escherichia coli, Haemophilus spp., Pasteurella spp., Salmonella spp., Staphylococcus spp., Streptococcus spp., Clostridium perfringens, Bordetella spp., Campylobacter spp., Corynebacterium pyogenes, Pseudomonas aeruginosa. and Mycoplasma spp. Colistin sulfate impairs the permeability of the bacterial cell walls by connecting to lypoproteins that leads to a change in the intracellular metabolism and causes death of Gram-negative bacteria including Escherichia coli, Pseudomonas aeruginosa, Klebsiella spp, Salmonella spp. and Proteus spp.
    After injection, Enronit is quickly resorbed from the injection site and distributed among the organs and tissues of the animal. Concentration of enrofloxacin in blood serum reaches its peak value after 1-2 hours, while concentration of colistin sulfate in blood serum reaches its peak value after 1 hour. Enrofloxacin and colistin sulfate are eliminated unchanged mostly with feces and partially with urine.



  • Dosage and route of administration
  • Dosage and route of administration

    Enronit can be used against the following diseases: in calves, lambs and piglets – colibacillosis, salmonellosis, pasteurellosis, respiratory and other diseases caused by microbes sensitive to enrofloxacin and colistin sulfate; in adult pigs – atrophic rhinitis, enzootic pneumonia and MMA syndrome.

  • Restrictions
  • Restrictions

    The treated animals may be slaughtered for food no sooner than 21 days after last injection of Enronit. In case of compulsory slaughter occurring before the above stated period, the meat of slaughtered animals can be used as feed for fur animals.

     

  • Publications
  • Publications
  • Treatment regimen
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