Enronit OR

A synergistic combination of enrofloxacin and colistin sulfate, the active substances of Enronit OR provides a wide range of antimicrobial activity against Gram-positive and Gram-negative microbes. The mechanism of action of enrofloxacin (a fluroquinolone derivative) is as follows: enrofloxacin inhibits the activity of gyrase (an enzyme affecting replication of DNA spiral in the bacterial cell nucleus), which allows it to disrupt protein synthesis and suppress the growth and development of Gram-positive and Gram-negative bacteria including Escherichia coli, Haemophilus spp, Pasteurella spp, Salmonella spp., Staphylococcus spp, Streptococcus spp, Clostridium perfringens, Bordetella spp, Campylobacter spp, Corynebacterium pyogenes, Pseudomonas aeruginosa, as well as Mycoplasma spp. The mechanism of action of colistin sulfate (a polypeptide antibiotic) is as follows: colistin sulfate impairs the permeability of bacterial cell walls by connecting to lypoproteins that leads to a change in the intracellular metabolism and causes death of Gram-negative bacteria including Escherichia coli, Pseudomonas aeruginosa, Klebsiella spp, Salmonella spp. and Proteus spp.
After oral application, enrofloxacin is quickly and fully absorbed in the gastrointestinal tract and distributed among the organs and tissues of the animal; enrofloxacin is excreted mostly unchanged and partially as metabolites with feces and urine. Colistin sulfate is scarcely absorbed in the gastrointestinal tract and does not accumulate in organs and tissues. It is excreted mostly unchanged with feces.

A synergistic combination of enrofloxacin and colistin sulfate, the active substances of Enronit OR provides a wide range of antimicrobial activity against Gram-positive and Gram-negative microbes. The mechanism of action of enrofloxacin (a fluroquinolone derivative) is as follows: enrofloxacin inhibits the activity of gyrase (an enzyme affecting replication of DNA spiral in the bacterial cell nucleus), which allows it to disrupt protein synthesis and suppress the growth and development of Gram-positive and Gram-negative bacteria including Escherichia coli, Haemophilus spp, Pasteurella spp, Salmonella spp., Staphylococcus spp, Streptococcus spp, Clostridium perfringens, Bordetella spp, Campylobacter spp, Corynebacterium pyogenes, Pseudomonas aeruginosa, as well as Mycoplasma spp. The mechanism of action of colistin sulfate (a polypeptide antibiotic) is as follows: colistin sulfate impairs the permeability of bacterial cell walls by connecting to lypoproteins that leads to a change in the intracellular metabolism and causes death of Gram-negative bacteria including Escherichia coli, Pseudomonas aeruginosa, Klebsiella spp, Salmonella spp. and Proteus spp.
After oral application, enrofloxacin is quickly and fully absorbed in the gastrointestinal tract and distributed among the organs and tissues of the animal; enrofloxacin is excreted mostly unchanged and partially as metabolites with feces and urine. Colistin sulfate is scarcely absorbed in the gastrointestinal tract and does not accumulate in organs and tissues. It is excreted mostly unchanged with feces.