Instructions for medications
Instructions for medications

Instruction for use of E-Selen

I. General information

1. Tradename of the veterinary medicinal product: Е-selen.

International nonproprietary name: sodium selenite and tocopherol acetate.

2. E-selen is colorless or light-yellow opalescent in transmitted light liquid.

Shelf-life of the medicinal product under the specified conditions is 2 years from the date of manufacture, after first opening – 14 days.

The use of the drug E-selen after the expiration date is prohibited.

3. E-selen is available in 50 and 100 ml glass vials hermetically sealed with rubber stoppers and aluminum caps with first opening control clips.

4. The veterinary medicinal product is stored in sealed original package, separately from food and feed, in a dry place, protected from direct sunlight, storage temperature range: 4°С to 25°С.

5. E-selen should be kept out of reach of children

6. Unused product should be disposed in accordance with the applicable legislation.

7. The veterinary drug E-selen is available without veterinary prescription.

II. Сomposition

8. Pharmaceutical form: solution for injections

1 ml of E-selen contains 0,5 mg of selen (in form of sodium selenite) and 50 mg of vitamin E as active substances, and excipients – up to 1 ml.

III. Pharmacological properties

9. E-selen replenishes vitamin E and selen deficiency in animals organism.

10. Vitamin E regulates oxidation-reduction processes and influences on carbohydrate- fat metabolism, potentize vitamins A and D3, works upon immunity state, general body resistance. Biological role of selen is connected with its antioxidant characteristics. It promotes excretion of toxicological agents out of body, Immunity improvement of animals.

Injection of the veterinary drug into organism causes quick increase of vitamin E and selen level in animals bode, metabolic processes recovery.

IV. Administration procedure

11. E-selen is used for prevention and treatment of diseases, caused by vitamin E and selen deficiency (white-muscle disease, traumatic myositis and cardiopathy, massive hepatic necrosis), and also while acute situational reactions and stress situations, reproduction and fetation disorder, retardation of growth and insufficient gain in weight, infectious and infective diseases, prophylactic immunization and dehelminthization, nitrate, heavy metals and mycotoxin poisoning.

12. Contraindications include high intra-patient animal sensitivity to selen, or surplus contents of selen in feed and animal body (alkali disease).

13. The veterinary drug is administered to animals intramuscularly or subcutaneously (to horses only intramuscularly) for prevention once, during 2-4 months, for treatment – once, during 7-10 days 2-3 times in the following doses: adult animals: 1 ml/50 kg of animal weight; growing stock 0,2 ml/10 kg of animal weight; dogs, cats, fur-bearing animal: 0,04 ml/1 kg of animal weight.

For convenience of small volume drug administration, it is possible to dilute it with sterile water or normal saline and mix thoroughly.

The veterinary drug is administered to poultry with drinking water at a dilution of 1:100 in a dose 1 ml/kg of poultry weight or 2 ml/l of potable water: on preventive purpose to chicken starting with day-old once during 2-3 weeks, to growing stock and mature birds – once a month; for treatment – 2-3 times 1-2 weeks apart. Curative dose may be increased by 1,5, and in regions with selen deficiency - increased fivefold.

14. Overdose of the medicinal product results in toxic events, that is why a dose per one animal should not exceed: for horses – 20 ml; cows – 15 ml; sheep, goats, swine – 5 ml.

Overdose of the medicinal product results in animal ataxia, dyspnoea, anorexia, abdominal pains (the grinding of teeth), salivation, cyanosis of visible mucous coats, and sometimes skin, tachycardia, perspiration increases, body temperature drops. Expired air and skin have garlic odour. Ruminants may have hypotonia and forestomach atony. Swine, dogs and cats may have vomit, pulmonary edema.

There are no specific antidotes. Sodium arsenite 0,01g/kg (once) in water solution, methionine should be administered orally. Sodium, glucose solution - intravenously. For hepatic function recovery glutamic acid, essentiale, vitamins: В1 and В6 should be applied. The veterinary drugs, containing butafosfan and carnitine are prescribed such as hepatoprotector and antioxidants. Unitiol, dicaptol and ethylene diamine tetraacetic acid should not be administered: chelate complex of selen is more deleteriolis, than selen itself.

15. No specific actions were reported at the first use and discontinuance of the drug.

16. The veterinary drug should be administered to pregnant and lactating females with caution under veterinary physician control. The veterinary drug is administered to young animals for the main indication, with caution under control of a veterinarian.

17. When a dose is missed, continue to administer the product in the same dose and according to the same schedule. It is not allowed to administer double dosage to compensate missed.

18. No adverse reactions were observed at the administration of E-selen if administered subject to the instructions for use.

19. Medicinal product interaction: combined administration with vitamin C reduces bioavailability of the veterinary drug E-selen. It is forbidden to combine administration with Arsenicum medication – chemical antagonism. The veterinary drug E-selen breaks up when interacting with heavy metals (hydrargyrum, cuprum, hard lead, stanum).

20. The slaughter of animals is allowed: for small ruminants and swine – no earlier than 14 days, for cattle - no earlier than 30 days after intramuscular or subcutaneous administration of the veterinary drug. Meat of animals, compulsorily slaughtered until the indicated period, can be used to feed carnivores.

V. Special precautions for use

21. General rules of personal hygiene and safety measures required during work with medical agents should be followed when handling E-selen.

22. People with hypersensitivity to the formulation constituent should avoid direct contact with the veterinary drug E-selen. It is prohibited to drink, smoke or eat while handling the product. Wash your hands with soap and water after handling the product. Use of the empty vials of E-selen for domestic purposes is prohibited; they must be disposed of along with household waste.

23. In case of eye or skin contact, rinse with plenty of water. In case of allergic response or occasional contact with human body it is necessary to apply to the hospital (having current Instructions for use of the product or the product label with you).