Doxylox

A steady start

Doxycycline

An antibiotic from the new generation of prolonged action tetracyclines for sanitation of sows before farrowing.

Maximum effect with a single injection

Easy dosing in pigs — 1 mL/20 kg

High efficacy against chlamydia and mycoplasmosis.

Description
An antibiotic from the new generation of prolonged action tetracyclines for sanitation of sows before farrowing.

Doxylox is a transparent, slightly viscous yellow brown to red brown liquid.

Packing: 100 mL glass bottles.
Composition
Composition

1 ml
Doxylox

200 mg doxycycline
Pharmacological properties
Pharmacological properties

Doxycycline is a semisynthetic antibiotic that belongs to the 3rd generation of the tetracycline group and is effective against Gram-positive and Gram-negative microbes including Escherichia coli., Haemophilus spp., Pasteurella spp., Salmonella spp., Staphylococcus spp., Streptococcus spp., Leptospira spp., Chlamidia spp, Clostridium perfringens, Listeria monocytogenes, Corynebacterium pyogenes, Rickettsiae spp.; as well as Mycoplasma spp.

Mode of action: doxycycline inhibits bacterial growth by inhibiting enzymes that act as catalysts for binding aminoacetyl-RNA to ribosomal acceptors, thus causing blocking of interactions between aminoacyl-tRNA with mRNA and disruption of microbial cell protein synthesis. After parenteral administration of the drug, doxycycline is quickly and fully absorbed from the injection site and reaches its therapeutic concentration in 0.5 to 1 hour. It easily penetrates into most animal organs and tissues and undergoes metabolism in the liver, forming inactive metabolites. The drug is eliminated mostly with bile and partially with urine.
Indications
Indications

Doxylox is prescribed for cattle, small ruminants, pigs to treat infections caused by doxycycline-sensitive microorganisms, including colibacillosis, salmonellosis, pasteurellosis, swine enzootic pneumonia, chlamydia- and staphylococcus-induced diseases, Glasser’s disease, and other diseases of bacterial and mycoplasmal etiology.
Dosage and route of administration
Dosage and route of administration
Doxylox is injected intramuscularly once at the following doses:

for cattle - 1.0 mL per 10 kg of animal body weight. If necessary, the drug may be administered once again after 48 hours following the first injection. If the required volume of the drug exceeds 2.5 mL for lambs, 5 mL for sheep and calves,and 10 mL for cattle, several injections in various injection sites shall be made in order to avoid a possible pain reaction;

for pigs - 0.5 mL per 10 kg of animal body weight. If necessary, the drug may be administered once again after 48 hours following the first injection. If the required volume of the drug exceeds 2.5 mL for piglets, 5 mL for adult pigs, several injections in various injection sites shall be made in order to avoid a possible pain reaction.
Restrictions
Restrictions

CONTRAINDICATIONS

Avoid using the drug concurrently with penicillin antibiotics and cephalosporins, as well as with calcium preparations due to a possible decrease in its activity. Avoid using the drug during pregnancy and the lactation period.

RESTRICTIONS

Treated animals can be slaughtered for human consumption not earlier than 21 days after the last injection of Doxylox was made. In the case of forced slaughter of animals before the established deadlines, the meat can be used for feeding fur-bearing animals.

SHELF LIFE

2 years from the date of manufacture; after first opening - 28 days.

Description
Composition
Pharmacological properties
Indications
Dosage and route of administration
Restrictions

An antibiotic from the new generation of prolonged action tetracyclines for sanitation of sows before farrowing.

Doxylox is a transparent, slightly viscous yellow brown to red brown liquid.

Packing: 100 mL glass bottles.

Composition

1 ml

Doxylox

200 mg doxycycline

Pharmacological properties

Doxycycline is a semisynthetic antibiotic that belongs to the 3rd generation of the tetracycline group and is effective against Gram-positive and Gram-negative microbes including Escherichia coli., Haemophilus spp., Pasteurella spp., Salmonella spp., Staphylococcus spp., Streptococcus spp., Leptospira spp., Chlamidia spp, Clostridium perfringens, Listeria monocytogenes, Corynebacterium pyogenes, Rickettsiae spp.; as well as Mycoplasma spp.

Mode of action: doxycycline inhibits bacterial growth by inhibiting enzymes that act as catalysts for binding aminoacetyl-RNA to ribosomal acceptors, thus causing blocking of interactions between aminoacyl-tRNA with mRNA and disruption of microbial cell protein synthesis. After parenteral administration of the drug, doxycycline is quickly and fully absorbed from the injection site and reaches its therapeutic concentration in 0.5 to 1 hour. It easily penetrates into most animal organs and tissues and undergoes metabolism in the liver, forming inactive metabolites. The drug is eliminated mostly with bile and partially with urine.

Indications

Doxylox is prescribed for cattle, small ruminants, pigs to treat infections caused by doxycycline-sensitive microorganisms, including colibacillosis, salmonellosis, pasteurellosis, swine enzootic pneumonia, chlamydia- and staphylococcus-induced diseases, Glasser’s disease, and other diseases of bacterial and mycoplasmal etiology.

Video

Dosage and route of administration

Doxylox is injected intramuscularly once at the following doses:

for cattle - 1.0 mL per 10 kg of animal body weight. If necessary, the drug may be administered once again after 48 hours following the first injection. If the required volume of the drug exceeds 2.5 mL for lambs, 5 mL for sheep and calves,and 10 mL for cattle, several injections in various injection sites shall be made in order to avoid a possible pain reaction;

for pigs - 0.5 mL per 10 kg of animal body weight. If necessary, the drug may be administered once again after 48 hours following the first injection. If the required volume of the drug exceeds 2.5 mL for piglets, 5 mL for adult pigs, several injections in various injection sites shall be made in order to avoid a possible pain reaction.

Restrictions

CONTRAINDICATIONS

Avoid using the drug concurrently with penicillin antibiotics and cephalosporins, as well as with calcium preparations due to a possible decrease in its activity. Avoid using the drug during pregnancy and the lactation period.

RESTRICTIONS

Treated animals can be slaughtered for human consumption not earlier than 21 days after the last injection of Doxylox was made. In the case of forced slaughter of animals before the established deadlines, the meat can be used for feeding fur-bearing animals.

SHELF LIFE

2 years from the date of manufacture; after first opening - 28 days.

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