Doxylox

A steady start
Cattle
Small cattle
Swine
Doxycycline

An antibiotic from the new generation of prolonged action tetracyclines for sanitation of sows before farrowing

A maximum effect with a single injection

Easy dosing in pigs - 1 mL / 20 kg

High efficiency against chlamydia and mycoplasmosis

  • Description
  • An antibiotic from the new generation of prolonged action tetracyclines for sanitation of sows before farrowing.

    Appearance: a transparent, slightly viscous brown liquid.

    Available as a sterile solution filled in 100 mL glass vials



    Doxylox
  • Composition
  • Composition
    1 ml Doxylox = 200 mg doxycycline
  • Pharmacological properties
  • Pharmacological properties

    Doxycycline, an active substance of the drug, is a semisynthetic antibiotic that belongs to the 3rd generation of the tetracycline group and is effective against Gram-positive and Gram-negative microbes including Escherichia coli., Haemophilus spp., Pasteurella spp., Salmonella spp., Staphylococcus spp., Streptococcus spp., Leptospira spp., Chlamidia spp, Clostridium perfringens, Listeria monocytogenes, Corynebacterium pyogenes, Rickettsiae spp, as well as Mycoplasma spp.

    The mechanism of bacterial growth-inhibition activity of doxycycline involves inhibition of enzymes that act as catalysts for binding aminoacetyl-RNA to ribosomal acceptors, which leads to blocking of interactions between aminoacyl-transport RNA with messenger RNA and disruption of microbial cell protein synthesis. After parenteral administration of the drug, doxycycline is quickly and fully absorbed from the injection site and reaches its therapeutic concentration after 0.5-1 hour. It easily penetrates into most animal organs and tissues and undergoes metabolism in the liver, forming inactive metabolites. The drug is eliminated mostly with bile and partially with urine.



  • Indications
  • Indications

    Doxylox is indicated for large and small cattle and pigs for treatment of infections caused by microorganisms sensitive to doxycycline, including colibacillosis, salmonellosis, pasteurellosis, swine enzootic pneumonia, chlamydia- and staphylococcus-induced diseases, Glasser’s disease, and other diseases of bacterial and mycoplasmal etiology.


  • Dosage and route of administration
  • Dosage and route of administration

    Doxylox is injected intramuscularly once at the following doses: 1.0 mL per 10 kg of animal weight (20 mg of doxycycline per 1 kg of animal weight) for cattle; 0.5 mL per 10 kg of animal weight (10 mg of doxycycline per 1 kg of animal weight) for pigs.

    If necessary, the drug may be administered once again after 48 hours following the first injection. If the required volume of the drug exceeds 2.5 mL for lambs and piglets, 5 mL for adult pigs, sheep and calves, and 10 mL for cattle, several injections in various sites shall be made in order to avoid a possible pain reaction.


  • Restrictions
  • Restrictions

    Treated animals may be slaughtered for food not eatlier than 21 days after the last injection of Doxylox. Meat from animals, forcedly slaughtered before the expiry of this period, can be used as feed to fur animals.



  • Publications
  • Publications
  • Treatment regimen

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