Doxylox

A steady start
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DoxyloxPhoto1
Doxycycline

An antibiotic from the new generation of prolonged action tetracyclines for sanitation of sows before farrowing.

Maximum effect with a single injection

Easy dosing in pigs — 1 mL/20 kg

High efficacy against chlamydia and mycoplasmosis.

  • Description
  • An antibiotic from the new generation of prolonged action tetracyclines for sanitation of sows before farrowing.

    Doxylox is a transparent, slightly viscous yellow brown to red brown liquid.

    Packing: 100 mLglass bottles.

    Doxylox
  • Composition
  • Composition
    1 ml
    Doxylox

    200 mg doxycycline

  • Pharmacological properties
  • Pharmacological properties

    Doxycycline is a semisynthetic antibiotic that belongs to the 3rd generation of the tetracycline group and is effective against Gram-positive and Gram-negative microbes including Escherichia coli., Haemophilus spp., Pasteurella spp., Salmonella spp., Staphylococcus spp., Streptococcus spp., Leptospira spp., Chlamidia spp, Clostridium perfringens, Listeria monocytogenes, Corynebacterium pyogenes, Rickettsiae spp.; as well as Mycoplasma spp.

    Mode of action: doxycycline inhibits bacterial growth by inhibiting enzymes that act as catalysts for binding aminoacetyl-RNA to ribosomal acceptors, thus causing blocking of interactions between aminoacyl-tRNA with mRNA and disruption of microbial cell protein synthesis. After parenteral administration of the drug, doxycycline is quickly and fully absorbed from the injection site and reaches its therapeutic concentration in 0.5 to 1 hour. It easily penetrates into most animal organs and tissues and undergoes metabolism in the liver, forming inactive metabolites. The drug is eliminated mostly with bile and partially with urine.

  • Indications
  • Indications

    Doxylox is prescribed for cattle, small ruminants, pigs to treat infections caused by doxycycline-sensitive microorganisms, including colibacillosis, salmonellosis, pasteurellosis, swine enzootic pneumonia, chlamydia- and staphylococcus-induced diseases, Glasser’s disease, and other diseases of bacterial and mycoplasmal etiology.

  • Dosage and route of administration
  • Dosage and route of administration

    Doxylox is injected intramuscularly once at the following doses:

    • for cattle - 1.0 mLper 10 kg of animal body weight (20 mg of the API/kg). If necessary, the drug may be administered once again after 48 hours following the first injection. If the required volume of the drug exceeds 2.5 mL for lambs, 5 mL for sheep and calves, and 10 mL for cattle, several injections in various injection sites shall be made in order to avoid a possible pain reaction
    • for pigs - 0.5 mLper 10 kg of animal body weight (10 mg of the API/kg). If necessary, the drug may be administered once again after 48 hours following the first injection. If the required volume of the drug exceeds 2.5 mL for piglets, 5 mL for adult pigs, several injections in various injection sites shall be made in order to avoid a possible pain reaction.

  • Restrictions
  • Restrictions

    CONTRAINDICATIONS

    Avoid using the drug concurrently with penicillin antibiotics and cephalosporins, as well as with calcium preparations due to a possible decrease in its activity. Avoid using the drug during pregnancy and the lactation period.

    RESTRICTIONS

    Treated animals can be slaughtered for human consumption not earlier than 21 days after the last injection of Doxylox was made. In the case of forced slaughter of animals before the established deadlines, the meat can be used for feeding fur-bearing animals.

    SHELF LIFE

    2 years from the date of manufacture; after first opening - 28 days.