Doxylox OR

Stable results

Swine

Poultry

Doxycycline

A professional antibacterial drug from the latest generation of tetracyclines

Highly stable in hard water up to 13°GH

The form of the solution reduces the risk of development of resistant microflora

Description
A professional antibacterial drug from the latest generation of tetracyclines, in the form of an oral solution for commercial swine production, and poultry farming.
Appearance: a transparent, light-brown to dark-brown viscous liquid.
Doxylox OR is packaged in 1000 mL plastic bottles or 5000 mL plastic cans sealed with tamper-evident screw-on caps.
Composition
Composition

1 ml Doxylox OR = 100 mg doxycycline
Pharmacological properties
Pharmacological properties

Doxylox OR belongs to the antimicrobial group. Doxycycline hyclate contained in the drug belongs to the tetracycline antibiotics. It has a bacteriostatic effect on Gram-positive and Gram-negative microorganisms, some protozoa, as well as on mycoplasma, including Escherichia coli, Haemophilus spp., Pasteurella spp., Salmonella spp., Staphylococcus spp., Streptococcus spp., Clostridium spp., Chlamydia spp., Listeria spp., Leptospira spp., Mycoplasma spp.

The mechanism of bacteriostatic action of doxycycline is based on the inhibition of enzymes that catalyze binding of the aminoacetyl-RNA with ribosomal acceptors, which results in blocking interaction of the aminoacyl-tRNA with the messenger RNA, and disruption of microbial cells protein synthesis. The drug is well absorbed from the gastrointestinal tract of poultry birds and is rapidly distributed to all organs and tissues of the body. The effective blood concentration is reached after 2-4 hours and is maintained for 18 - 24 hours. The drug easily penetrates into most organs and tissues, it is metabolized in the liver to inactive metabolites and is mainly excreted with feces and urine.
Indications
Indications

Doxylox OR is used for treatment of infectious diseases in pigs and poultry caused by microorganisms sensitive to doxycycline, such as Pasteurella, Bordetella, E. coli, Salmonella, Staphylococcus, Streptococcus, Clostridium, Rickettsia, Chlamydia, and Mycoplasma
Dosage and route of administration
Dosage and route of administration

Doxylox OR shall be given with drinking water to animals individually or to a group, in the following doses: for poultry, 0.5–1 mL per 1 L of drinking water (equal to 50–100 mg of doxycycline per 1 L of water) for 3–5 days; for pigs, a single dose of 1 mL per 10 kg of body weight (equal to 10 mg of doxycycline per kg of animal body weight), for 5 days.

When the drug is used in groups, during treatment animals and poultry must receive drug-containing water only. Medical solution of Doxylox OR to be consumed over a day shall be prepared daily. When administering, do not use rusty drinking bowls.
Restrictions
Restrictions

Slaughter of pigs for meat is permitted not earlier than after 10 days; of poultry, not earlier than after 6 days after the last administration of Doxylox OR. Meat from animals, forcedly slaughtered before the expiration of the specified term may be used as food for fur animals. Due to the accumulation of doxycycline in eggs, the drug may not be used to laying hens.
Publications
Publications
Treatment regimen

Description
Composition
Pharmacological properties
Indications
Dosage and route of administration
Restrictions

A professional antibacterial drug from the latest generation of tetracyclines, in the form of an oral solution for commercial swine production, and poultry farming.
Appearance: a transparent, light-brown to dark-brown viscous liquid.
Doxylox OR is packaged in 1000 mL plastic bottles or 5000 mL plastic cans sealed with tamper-evident screw-on caps.

Composition

1 ml Doxylox OR = 100 mg doxycycline

Pharmacological properties

Doxylox OR belongs to the antimicrobial group. Doxycycline hyclate contained in the drug belongs to the tetracycline antibiotics. It has a bacteriostatic effect on Gram-positive and Gram-negative microorganisms, some protozoa, as well as on mycoplasma, including Escherichia coli, Haemophilus spp., Pasteurella spp., Salmonella spp., Staphylococcus spp., Streptococcus spp., Clostridium spp., Chlamydia spp., Listeria spp., Leptospira spp., Mycoplasma spp.

The mechanism of bacteriostatic action of doxycycline is based on the inhibition of enzymes that catalyze binding of the aminoacetyl-RNA with ribosomal acceptors, which results in blocking interaction of the aminoacyl-tRNA with the messenger RNA, and disruption of microbial cells protein synthesis. The drug is well absorbed from the gastrointestinal tract of poultry birds and is rapidly distributed to all organs and tissues of the body. The effective blood concentration is reached after 2-4 hours and is maintained for 18 - 24 hours. The drug easily penetrates into most organs and tissues, it is metabolized in the liver to inactive metabolites and is mainly excreted with feces and urine.

Indications

Doxylox OR is used for treatment of infectious diseases in pigs and poultry caused by microorganisms sensitive to doxycycline, such as Pasteurella, Bordetella, E. coli, Salmonella, Staphylococcus, Streptococcus, Clostridium, Rickettsia, Chlamydia, and Mycoplasma

Video

Dosage and route of administration

Doxylox OR shall be given with drinking water to animals individually or to a group, in the following doses: for poultry, 0.5–1 mL per 1 L of drinking water (equal to 50–100 mg of doxycycline per 1 L of water) for 3–5 days; for pigs, a single dose of 1 mL per 10 kg of body weight (equal to 10 mg of doxycycline per kg of animal body weight), for 5 days.

When the drug is used in groups, during treatment animals and poultry must receive drug-containing water only. Medical solution of Doxylox OR to be consumed over a day shall be prepared daily. When administering, do not use rusty drinking bowls.

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Restrictions

Slaughter of pigs for meat is permitted not earlier than after 10 days; of poultry, not earlier than after 6 days after the last administration of Doxylox OR. Meat from animals, forcedly slaughtered before the expiration of the specified term may be used as food for fur animals. Due to the accumulation of doxycycline in eggs, the drug may not be used to laying hens.

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