Doxylox OR

Stable results
Swine
Poultry
Doxycycline

A professional antibacterial drug from the latest generation of tetracyclines

Highly stable in hard water up to 13°GH

The form of the solution reduces the risk of development of resistant microflora

  • Description
  • A professional antibacterial drug from the latest generation of tetracyclines, in the form of an oral solution for commercial swine production, and poultry farming.
    Appearance: a transparent, light-brown to dark-brown viscous liquid.
    Doxylox OR is packaged in 1000 mL plastic bottles or 5000 mL plastic cans sealed with tamper-evident screw-on caps.

    Doxylox OR
  • Composition
  • Composition
    1 ml Doxylox OR = 100 mg doxycycline
  • Pharmacological properties
  • Pharmacological properties

    Doxylox OR belongs to the antimicrobial group. Doxycycline hyclate contained in the drug belongs to the tetracycline antibiotics. It has a bacteriostatic effect on Gram-positive and Gram-negative microorganisms, some protozoa, as well as on mycoplasma, including Escherichia coli, Haemophilus spp., Pasteurella spp., Salmonella spp., Staphylococcus spp., Streptococcus spp., Clostridium spp., Chlamydia spp., Listeria spp., Leptospira spp., Mycoplasma spp.

    The mechanism of bacteriostatic action of doxycycline is based on the inhibition of enzymes that catalyze binding of the aminoacetyl-RNA with ribosomal acceptors, which results in blocking interaction of the aminoacyl-tRNA with the messenger RNA, and disruption of microbial cells protein synthesis. The drug is well absorbed from the gastrointestinal tract of poultry birds and is rapidly distributed to all organs and tissues of the body. The effective blood concentration is reached after 2-4 hours and is maintained for 18 - 24 hours. The drug easily penetrates into most organs and tissues, it is metabolized in the liver to inactive metabolites and is mainly excreted with feces and urine.

     

  • Indications
  • Indications

    Doxylox OR belongs to the antimicrobial group. Doxycycline hyclate contained in the drug belongs to the tetracycline antibiotics. It has a bacteriostatic effect on Gram-positive and Gram-negative microorganisms, some protozoa, as well as on mycoplasma, including Escherichia coli, Haemophilus spp., Pasteurella spp., Salmonella spp., Staphylococcus spp., Streptococcus spp., Clostridium spp., Chlamydia spp., Listeria spp., Leptospira spp., Mycoplasma spp.

    The mechanism of bacteriostatic action of doxycycline is based on the inhibition of enzymes that catalyze binding of the aminoacetyl-RNA with ribosomal acceptors, which results in blocking interaction of the aminoacyl-tRNA with the messenger RNA, and disruption of microbial cells protein synthesis. The drug is well absorbed from the gastrointestinal tract of poultry birds and is rapidly distributed to all organs and tissues of the body. The effective blood concentration is reached after 2-4 hours and is maintained for 18 - 24 hours. The drug easily penetrates into most organs and tissues, it is metabolized in the liver to inactive metabolites and is mainly excreted with feces and urine.

     

  • Dosage and route of administration
  • Dosage and route of administration

    Doxylox OR shall be given with drinking water to animals individually or to a group, in the following doses: for poultry, 0.5–1 mL per 1 L of drinking water (equal to 50–100 mg of doxycycline per 1 L of water) for 3–5 days; for pigs, a single dose of 1 mL per 10 kg of body weight (equal to 10 mg of doxycycline per kg of animal body weight), for 5 days.

    When the drug is used in groups, during treatment animals and poultry must receive drug-containing water only. Medical solution of Doxylox OR to be consumed over a day shall be prepared daily. When administering, do not use rusty drinking bowls.

     

  • Restrictions
  • Restrictions

    Slaughter of pigs for meat is permitted not earlier than after 10 days; of poultry, not earlier than after 6 days after the last administration of Doxylox OR. Meat from animals, forcedly slaughtered before the expiration of the specified term may be used as food for fur animals. Due to the accumulation of doxycycline in eggs, the drug may not be used to laying hens.

     

  • Publications
  • Publications
  • Treatment regimen
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