Ditrim

Cattle
Pets
Swine
Other animals
Sulfadimine, trimethoprim

A complex antibacterial drug with synergistic components

The synergy of the components prevents the development of resistance

A doubled strength of the antimicrobial action

Suitable for rotation with the most modern antibiotics

  • Description
  • Ditrim is a leading complex veterinary antibacterial drug in the RF and CIS among the trimethoprim- and sulfadimezin-based preparations.

    Appearance: a sterile light yellow solution.

    Ditrim is manufactured in 20, 50 and 100 mL sealed glass vials.


    Ditrim
  • Composition
  • Composition
    1 ml Ditrim = 200 mg sulfadimezin, 40 mg trimethoprim
  • Pharmacological properties
  • Pharmacological properties

    Sulfadimezin and trimethoprim, the active substances of Ditrim, enhance each other’s activity through successive impact on the metabolism of n-aminobenzoic and folic acids which takes place in the microbial cell, thus ensuring a wide range of antibacterial activity. Ditrim is effective against Gram-positive and Gram-negative microbes. The drug has proved to be effective against the following bacteria: E.coli, Clostridium spp., Salmonella spp., Proteus spp., Bacillus anthracis, Pasteurella spp., Haemophilus spp., Vibrio spp., Staphylococcus spp., Streptococcus spp., Shigella spp., Corynebacterium spp., Klebsiella spp., Fusobacterium spp., Bordetella spp., Brucella spp, Campylobacter spp., and Enterobacter spp.
    After Ditrim has been injected intramuscularly, it resorbs and reaches its peak concentration within 2-3 hours after injection. After that, the drug maintains its antibacterial activity for 24 hours. Ditrim is eliminated mostly with urine; in lactating animals, it can also be partially eliminated with milk.

  • Indications
  • Indications

    Ditrim can be used as a curative measure against the following bacterial infections caused by microbes sensitive to sulfadimezine and trimethoprim :
    For bovine cattle – bronchopneumonia, colibacillosis, paratyphoid fever, metritis, vibrionic diarhhea etc.
    For pigs – pulmonary infections, metritis, bacillary dysentery, pasteurellosis, paratyphoid fever, colibacillosis, MMA syndrome, malignant edema, eimeriosis, isosporiasis etc.
    For horses – bacteria-caused pneumonia, septicopyaemia, paratyphoid fever, colt diarrhea;
    For dogs – intestinal and pulmonary infections, cystoisosporosis;

  • Dosage and route of administration
  • Dosage and route of administration

    To farm animals, Ditrim is administered in the neck by an intramuscular injection once a day at a dose of 1 mL per 10 kg of animal weight (for horses, i.v. route is recommended). In case of a severe disease, the same dose is administered twice a day at 12 hours intervals during the first 2-3 days.

    The duration of treatment is 3 to 7 days.. Due to a possible pain reaction, it is recommended to inject no more than 10 mL of the drug to the same site to cattle, pigs and horses, and no more than 5 mL to piglets and dogs.

    When used in the recommended doses, side effects and complications are generally not observed.


  • Restrictions
  • Restrictions

    Slaughter of animals for meat is permitted not earlier than 28 days after the last injection of Ditrim. The Meat from animals, forcedly slaughtered before the expiry of this period, can be used as feed to fur animals. The milk from lactating animals is allowed to use for food during 5 days after the last injection. The milk obtained during treatment and within 5 days after the last injection may be used as animal feed after boiling.


  • Publications
  • Publications
  • Treatment regimen
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