The drug shall be administered to animals once in accordance with all aseptic and antiseptic rules:
to cattle, Clozatrem shall be administered intramuscularly or subcutaneously at a dose of 0.5 mL per 10 kg of animal body weight (i. e. 2.5 mg of API/kg) to treat nematodosis and fasciolasis; 1 mL per 10 kg of animal body weight (i. e. 5.0 mg of API/kg) to treat hypodermatosis
to sheep and goats, Clozatrem shall be applied subcutaneously at a dose of 0.5 mL per 10 kg of animal body weight (i. e. 2.5 mg of API/kg) to treat nematodosis and oestrosis; 1 mL per 10 kg of animal body weight (i. e. 5.0 mg of API/kg) to treat fasciolasis. If the required drug volume exceeds 20 mL in adult cattle and 10 mL in sheep, goats, and calves, several injections in different injection sites shall be made in order to avoid any possible pain reaction. Prior to mass treatment with Clozatrem, each drug batch shall be first tested in a small group of animals (5 to 7 animals) of different fatness. If no complications occurred within 3 days, the drug is used throughout the livestock. Animals shall receive therapeutic treatment against helminthes, if medically required; animals shall receive preventive treatment against helminthes before transferring them to stables and in spring before transferring to pastures; against gadfly invasions - straight after the end of gadfly swarming season and in spring (February - March).
Avoid using Clozatrem in milked animals, as well as in cows, sheep, goats, less than 30 days before calving or lambing, as the drug is excreted with milk. Avoid using Clozatrem in the animals suffering from contagious diseases, as well as in weakened or debilitated animals. Avoid using the drug concurrently with organochlorine and organophosphorus insecticides.