Clozatrem

Reliable protection against parasites

Closantel

Treatment and prevention of helminthiasis and gadfly invasions, high efficiency against fascioliasis

Maximum efficiency in the treatment of fascioliasis

Therapy of nematosis and gadfly invasions

Directed action of the injectable solution

Description
A drug for the treatment and prevention of helminthiasis and gadfly invasions in large and small cattle.

Appearance: a clear pale with yellow to light brown liquid .

Clozatrem is available in the form of a sterile solution packaged in 100 and 250 ml glass flasks.
Composition
Composition

1 ml
Clozatrem

50 mg closantel
Pharmacological properties
Pharmacological properties

Closantel, the active substance of the drug, is a salicylamide derivative and has a wide range of antiparasitic action. It is very effective against larvae and mature forms of nematodes including Haemonchus spp., Nematodirus spp, Trichostrongylus spp., Ostertagia spp, Oesophagostomum radiatum, Bunostomum spр. and Chabertia ovis, mature and immature Fasciola hepatica and mature Fasciola gigantica (trematodes) as well as larva forms of gadflies including Hypoderma bovis, Hypoderma lineatum and Oestrus ovis being parasites of large and small cattle. The mechanism of action of closantel is as follows: closantel affects the processes of phosphorylation and electron transfer leading to metabolism disruption and death of the parasite. After parenteral administration of the drug, closantel absorbs quickly from the injection site and distributes along the animal’s organs and tissues; concentration of closantel reaches its peak values in blood after 10-12 hours and remains in the blood at a therapeutic level for up to 10 days after injection. Closantel is eliminated unchanged mostly with bile; in lactating animals, it can also be partially excreted in milk.
Indications
Indications

Clozatrem can be used as a therapeutic and preventive measure against the following diseases: in cattle - haemonchosis, oesophagostomiasis, bunostomosis, trichostrongylosis, ostertagiosis, fasciolasis and hypodermosis; in sheep and goats - haemonchosis, nematodyrosis, trichostrongylosis, chabertiosis, bunostomosis, oesophagostomiasis, fasciolasis and oestrosis.
Dosage and route of administration
Dosage and route of administration

The drug shall be administered to animals once in accordance with all aseptic and antiseptic rules:
- for bovine cattle, Clozatrem shall be administered intramuscularly or subcutaneously with the dose being as follows: 0.5 mL per 10 kg of animal weight (2.5 mg of closantel per 1 kg) in nematodosis and fasciolasis; 1 mL per 10 kg of animal weight (5.0 mg of closantel per 1 kg) in hypodermatosis;
- for sheep and goats, Clozatrem shall be applied subcutaneously with the dose being as follows: 0.5 mL per 10 kg of animal weight (2.5 mg of closantel per 1 kg) in nematodosis and oestrosis; 1 mL per 10 kg of animal weight (5.0 mg of closantel per 1 kg) in fasciolasis.
If the required drug volume exceeds 20 mL for bovine animals and 10 mL for sheep, goats and calves, several injections in different sites shall be made in order to avoid possible pain reaction.
Before mass application of Clozatrem, each drug batch shall be first tested on a small group of animals (5-7 heads) of different fatness. If no complications are observed after 3 days, the drug batch can be used for the rest of the herd.
Animals shall receive therapeutic treatment against helminthes if they experience relevant symptoms; animals shall receive preventive treatment against helminthes before transferring to stables and in spring before transferring to pastures; against gadfly invasions – straight after the end of gadfly swarming season and in spring (February – March).
Restrictions
Restrictions

Milk produced by treated animals shall be used as food no sooner than 14 days after last injection of Clozatrem. It can be used as animal feed. Clozatrem also shall not be applied to weakened and emaciated animals or animals with infectious diseases. It also shall not be used simultaneously with chlorine-organic and phosphor-organic medical drugs.

Description
Composition
Pharmacological properties
Indications
Dosage and route of administration
Restrictions

A drug for the treatment and prevention of helminthiasis and gadfly invasions in large and small cattle.

Appearance: a clear pale with yellow to light brown liquid .

Clozatrem is available in the form of a sterile solution packaged in 100 and 250 ml glass flasks.

Composition

1 ml

Clozatrem

50 mg closantel

Pharmacological properties

Closantel, the active substance of the drug, is a salicylamide derivative and has a wide range of antiparasitic action. It is very effective against larvae and mature forms of nematodes including Haemonchus spp., Nematodirus spp, Trichostrongylus spp., Ostertagia spp, Oesophagostomum radiatum, Bunostomum spр. and Chabertia ovis, mature and immature Fasciola hepatica and mature Fasciola gigantica (trematodes) as well as larva forms of gadflies including Hypoderma bovis, Hypoderma lineatum and Oestrus ovis being parasites of large and small cattle. The mechanism of action of closantel is as follows: closantel affects the processes of phosphorylation and electron transfer leading to metabolism disruption and death of the parasite. After parenteral administration of the drug, closantel absorbs quickly from the injection site and distributes along the animal’s organs and tissues; concentration of closantel reaches its peak values in blood after 10-12 hours and remains in the blood at a therapeutic level for up to 10 days after injection. Closantel is eliminated unchanged mostly with bile; in lactating animals, it can also be partially excreted in milk.

Indications

Clozatrem can be used as a therapeutic and preventive measure against the following diseases: in cattle - haemonchosis, oesophagostomiasis, bunostomosis, trichostrongylosis, ostertagiosis, fasciolasis and hypodermosis; in sheep and goats - haemonchosis, nematodyrosis, trichostrongylosis, chabertiosis, bunostomosis, oesophagostomiasis, fasciolasis and oestrosis.

Video

Dosage and route of administration

The drug shall be administered to animals once in accordance with all aseptic and antiseptic rules:
- for bovine cattle, Clozatrem shall be administered intramuscularly or subcutaneously with the dose being as follows: 0.5 mL per 10 kg of animal weight (2.5 mg of closantel per 1 kg) in nematodosis and fasciolasis; 1 mL per 10 kg of animal weight (5.0 mg of closantel per 1 kg) in hypodermatosis;
- for sheep and goats, Clozatrem shall be applied subcutaneously with the dose being as follows: 0.5 mL per 10 kg of animal weight (2.5 mg of closantel per 1 kg) in nematodosis and oestrosis; 1 mL per 10 kg of animal weight (5.0 mg of closantel per 1 kg) in fasciolasis.
If the required drug volume exceeds 20 mL for bovine animals and 10 mL for sheep, goats and calves, several injections in different sites shall be made in order to avoid possible pain reaction.
Before mass application of Clozatrem, each drug batch shall be first tested on a small group of animals (5-7 heads) of different fatness. If no complications are observed after 3 days, the drug batch can be used for the rest of the herd.
Animals shall receive therapeutic treatment against helminthes if they experience relevant symptoms; animals shall receive preventive treatment against helminthes before transferring to stables and in spring before transferring to pastures; against gadfly invasions – straight after the end of gadfly swarming season and in spring (February – March).

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Restrictions

Milk produced by treated animals shall be used as food no sooner than 14 days after last injection of Clozatrem. It can be used as animal feed. Clozatrem also shall not be applied to weakened and emaciated animals or animals with infectious diseases. It also shall not be used simultaneously with chlorine-organic and phosphor-organic medical drugs.

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