Proven efficacy against mastitis1
No restrictions for milk consumption
Fast therapeutic effect due to reaching peak plasma concentrations within 1 to 2 hours
Easy dosage: one injection - one injection site
The drug may be virtually used before slaughter, as the restriction period for meat consumption is short
An antibacterial broad-spectrum drug to treat pigs and cattle without restrictions for milk consumption.
Ceftonit is a white to dark creamy suspension.
Packing: 50 and 100 mL glass bottles.
50 mg ceftiofur
Ceftiofur (the third generation cephalosporin antibiotic) is very effective against a wide range of Gram-positive and Gram-negative bacteria including β-lactamase producing strains and some anaerobic bacteria: Escherichia coli, Pasteurella (Mannheimia) haemolytica, Pasteurella multocida, Haemophilus somnus, Actinobacillus pleuropneumoniae, Haemophilus parasuis, Salmonella cholerasuis, Streptococcus Suis, Streptococcus zooepidemicus, Streptococcus equi, Pasteurella spp, Staphilococcus spp., Actynomyces pyogenes, Salmonells typhimurium, Streptococcus agalactiae, S. dysgalactiae, S. bovis, Klebsiela, Citrobacter, Enterobacter, Bacillus spp., Proteus spp., Fusobacterium necrophorum, and Porphiromonas assacharolytica (Bacteroides melaninogenicus). Administered parenterally, ceftiofur is rapidly metabolized to desfuroylceftiofur, reaches therapeutic concentration in the body, and maintains it for 20 hours. The maximum concentration of the antibiotic in the animal body is achieved in 0.5 to 2 hours after Ceftonit was administered. Desfuroilceftiofur is excreted from the body mainly through the kidneys.
Ceftonit is prescribed to treat bacterial diseases of the respiratory tract caused by Pasteurella haemolytica, Pasteurella multocida, and Haemophilus somnus, and necrobacillosis caused by Fusobacterium necrophorum and Porphiromonas assacharolytica (Bacteroides melaninogenicus). In cows, it is prescribed to treat acute endometritis. In pigs, it can be used to treat infectious respiratory diseases caused by Pasteurella haemolytica, Pasteurella multocida, Actinobacillus pleuropneumoniae, and Streptococcus suis.
Due to Flunex - Ceftonit combination administered to cows suffering from mastitis at a reduced dose (1 mL/45 kg of animal body weight), the recovery period in the case of purulent2 catarrhal mastitis can be reduced by 12 hours, compared to a ceftonit monotherapy2.
2 - The studies were conducted in a farm (Marksovsky district, Saratov region). The experiment included black-and-white cows taken from a dairy herd; the average weight was 450 to 550 kg and the age - 2 to 5 years; clinical or subclinical mastitis was diagnosed in all animals. Following the principle of analogues, while taking into account the diagnosis, 4 groups (10 animals each) were formed.
3 - The number of somatic cells per 1 cm3 does not exceed 170 000
| Animal species | Indications | Route of administration | Dosage | Frequency of administration | n Treatment period, days |
| Cattle | Respiratory diseases | Subcutaneously | 1 mL/50 kg | Once a day | 3-5 |
| Necrobacillosis | 3 | ||||
| Endometritis | 5 | ||||
| Pigs | Respiratory diseases | Intramuscularly | y 1 mL/16 kg | 3 |
Hypersensitivity of an animal to ceftiofur or other β-lactam antibiotics. Avoid using Ceftonit concurrently with tetracyclines, chloramphenicol, aminoglycosides, furosemide, and ethacrylic acid.
Cattle can be slaughtered for human consumption no earlier than 5 days, pigs - no earlier than 8 days after the last dose of the product was administered. In the case of forced slaughter of animals before the established deadlines, the meat can be used for feeding furbearing animals.
No restrictions set for consumption of the milk, obtained from the milked cows being treated with the drug.
3 years from the date of manufacture; after first opening - 28 days.
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