Azitronit

Hitting targets
КРС - изображение NITA FARM
Свиньи - изображение NITA FARM
МРС - изображение NITA FARM
Azithromycin

The first highly effective and safe azithromycin-based antibiotic¹ to treat and to prevent respiratory, gastrointestinal, and other infections in livestock animals.

Next-generation antibiotic

Targeted action2

Protection for up to 7 days after the last injection3

Improved condition of an animal within the first 10 to 12 hours4.




_______________________
1 - The first domestic azithromycin-based drug in veterinary pharmaceuticals
2 - The drug penetrates into the cells of the immune system and migrates to the focus of inflammation with them
3 - It exhibits antibiotic action due to its high ability to be accumulated in inflamed tissues
4 - Proven in practice during testing (due to its unique properties, incl. anti-inflammatory and immunomodulatory effects)
  • Description
  • The first highly effective and safe azithromycin-basedantibiotic to treat and to prevent respiratory, gastrointestinal, and other infections in livestock animals.

    Azitronit is a clear colourless to yellow liquid. Packing: 100 mL glass bottles, sealed with rubber stoppers, flip-off caps, and tamper-evident clips. 





    ____________________

    1 - The first domestic azithromycin-based drug in veterinary pharmaceuticals

    Azitronit
  • Composition
  • Composition
    1 ml
    Azitronit

    100 mg azithromycin

  • Pharmacological properties
  • Pharmacological properties

    Azithromycin is a broad-spectrum antibiotic of macrolide group (azalides subdivision) taking bacteriocidal/bacterial growth-inhibitory effect on Gram-negative (Actinobacillus lignieresi, Haemophilus spp., Moraxella spp., Bordetella spp., Campylobacter spp., Legionella pneumophila, Salmonella spp., Escherichia spp., Pasteurella (Mannheimia) haemolytica, Pasteurella multocida, Haemophilus parasuis) and Gram-positive (Listeria spp., Staphylococcus aureus, Staphylococcus spp., Streptococcus spp., Streptococcus pneumoniae, Streptococcus pyogenes, Enterococcus faecalis, Erysipelothrix insidiosa) bacteria, some anaerobic bacteria (Сlostridium perfringens, Fusobacterium spp.), micoplasma (Mycoplasma pneumoniae), Chlamydia pneumoniae, and spirochetes (Borrelia spp.).

    Mode of action: azithromycin inhibits protein biosynthesis by bacteria ribosome (peptide bonds between amino acids and peptide chain is getting broken). 

    Azithromycin exerts postantibiotic effect, i. e. persistent inhibition of bacterial activity after their short-term contact with the anti-infective drug. The basis of the effect consists in irreversible changes in microorganism ribosome, thus causing stable translocation block. Due to this, general antibacterial activity of the veterinary drug is getting more pronounced and prolonged, lasting for the term, required for re-synthesis of new functional proteins in microbial cell.

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    5 - Penicillin-sensitive
    6 - Methicillin-sensitive
    7 - ATCC 29212
    8 - АТСС 25922

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    9 - The chart is compiled regarding a course of treatment, by averaged values.
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    10 - Within the described experiment, the efficacy of the drug was studied in 105 animals of black-and-white calves, aged 2 to 5 months, weighing 60 to 100 kg. Groups were selected on an analogue basis and were comparable; the drugs were administered as per the instructions.

    11 - The tests were carried out in 40 white pigs, aged 1.5 to 2 months, weighing 10 to 18 kg with a gastroenteritis diagnosis confirmed

  • Indications
  • Indications

    Azitronit is prescribed for cattle, sheep, pigs to treat bacterial infection of respiratory system, gastrointestinal, and genito-urinary system, and also infection of skin and soft tissues, caused by azithromycin-sensitive microorganism, for therapy of necrobacillosis, pigs erysipelas, spirochetosis, and mycoplasmal infections.

  • Dosage and route of administration
  • Dosage and route of administration

    Animal species

    Dosage

    Route and frequency of administration

    Treatment period

    Cattle, small ruminants, pigs

    1 mL/20 kg

    Intramuscularly, once every 24 hours

    2 days, repeated injection, if required

    CONTRAINDICATIONS

    Avoid applying the drug in lactating animals, animals suffering from renal and hepatic insufficiency, as well as in those with hypersensitivity to macrolide antibiotics.

  • Restrictions
  • Restrictions

    Cattle and sheep can be slaughterer no earlier than 40 days, pigs - no earlier than 35 days after the last administration of the veterinary drug. In the case of forced slaughter of animals before the established deadlines, the meat can be used for feeding fur-bearing animals.

    SHELF LIFE

    2 years from the date of manufacture; after first opening - 30 days.

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