Azithromycin is a broad-spectrum antibiotic of macrolide group (azalides subdivision) taking bacteriocidal/bacterial growth-inhibitory effect on Gram-negative (Actinobacillus lignieresi, Haemophilus spp., Moraxella spp., Bordetella spp., Campylobacter spp., Legionella pneumophila, Salmonella spp., Escherichia spp., Pasteurella (Mannheimia) haemolytica, Pasteurella multocida, Haemophilus parasuis) and Gram-positive (Listeria spp., Staphylococcus aureus, Staphylococcus spp., Streptococcus spp., Streptococcus pneumoniae, Streptococcus pyogenes, Enterococcus faecalis, Erysipelothrix insidiosa) bacteria, some anaerobic bacteria (Сlostridium perfringens, Fusobacterium spp.), micoplasma (Mycoplasma pneumoniae), Chlamydia pneumoniae, and spirochetes (Borrelia spp.).
Mode of action: azithromycin inhibits protein biosynthesis by bacteria ribosome (peptide bonds between amino acids and peptide chain is getting broken).
Azithromycin exerts postantibiotic effect, i. e. persistent inhibition of bacterial activity after their short-term contact with the anti-infective drug. The basis of the effect consists in irreversible changes in microorganism ribosome, thus causing stable translocation block. Due to this, general antibacterial activity of the veterinary drug is getting more pronounced and prolonged, lasting for the term, required for re-synthesis of new functional proteins in microbial cell.
- ATCC 29212
- АТСС 25922
- The chart is compiled regarding a course of treatment, by averaged values.
10 - Within the described experiment, the efficacy of the drug was studied in 105 animals of black-and-white calves, aged 2 to 5 months, weighing 60 to 100 kg. Groups were selected on an analogue basis and were comparable; the drugs were administered as per the instructions.
11 - The tests were carried out in 40 white pigs, aged 1.5 to 2 months, weighing 10 to 18 kg with a gastroenteritis diagnosis confirmed