Amoxicillin is a broad-spectrum penicillin antibiotic, having bactericidal effect on most Gram-positive and Gram-negative microorganisms, including β-lactamase producing strains: Escherichia coli, Salmonella spp., Pasteurella spp., Clostridium spp., Staphylococcus spp., Erysipelothrix rhusiopathiae, Bordetella bronchiseptica, Haemophilus spp., Streptococcus spp., Klebsiella spp., Bacillus anthracis, Campylobacter spp., and Actinomyces (Corynebacterium) pyogenes.
Amoxicillin is a penicillin family antibiotic.
Mode of action: the drug disrupts the process of mucopeptide (a component of microbial cell wall) synthesis by inhibiting transpeptidase and carboxypeptidase activity, which leads to disruption of osmotic balance and destruction of the microbial cell. Clavulanic acid, inhibiting β-lactamase, protects amoxicillin from the enzyme.
The drug has a rapid bactericidal effect, while combined amoxicillin and clavulanic acid formulation affects penicillin-resistant microorganisms, among others.
Amoxicillin and clavulanic acid are well absorbed from the gastrointestinal tract and penetrate into the organs and tissues of the animal body, with their therapeutic concentrations retained for at least 12 hours after Amoxigard WS was administered; they are excreted mainly with urine and partially with bile, mainly in an unchanged form. Feed intake does not significantly affect the absorption of the drug.