Protected complex of clavulanic acid and amoxicillin
Nanostructure that retains the active form of active substances
Broad spectrum due to synergy between drug components.
A combined water-soluble drug based on amoxycillin and clavulanic acid that works against the resistance to β-lactam antibiotics.
Amoxygard WS is a light yellow to yellow powder.
Packing: 1 kg bags made of a composite material based on aluminum foil.
500 mg amoxicillin
125 mg clavulanic acid
Amoxicillin is a broad-spectrum penicillin antibiotic, having bactericidal effect on most Gram-positive and Gram-negative microorganisms, including β-lactamase producing strains: Escherichia coli, Salmonella spp., Pasteurella spp., Clostridium spp., Staphylococcus spp., Erysipelothrix rhusiopathiae, Bordetella bronchiseptica, Haemophilus spp., Streptococcus spp., Klebsiella spp., Bacillus anthracis, Campylobacter spp., and Actinomyces (Corynebacterium) pyogenes.
Amoxicillin is a penicillin family antibiotic.
Mode of action: the drug disrupts the process of mucopeptide (a component of microbial cell wall) synthesis by inhibiting transpeptidase and carboxypeptidase activity, which leads to disruption of osmotic balance and destruction of the microbial cell. Clavulanic acid, inhibiting β-lactamase, protects amoxicillin from the enzyme.
The drug has a rapid bactericidal effect, while combined amoxicillin and clavulanic acid formulation affects penicillin-resistant microorganisms, among others.
Amoxicillin and clavulanic acid are well absorbed from the gastrointestinal tract and penetrate into the organs and tissues of the animal body, with their therapeutic concentrations retained for at least 12 hours after Amoxigard WS was administered; they are excreted mainly with urine and partially with bile, mainly in an unchanged form. Feed intake does not significantly affect the absorption of the drug.
Amoxygard WS is prescribed for pigs and poultry to prevent and to treat diseases of bacterial etiology, including colibacteriosis, salmonellosis, pasteurellosis, bronchopneumonia, necrotizing enteritis, campylobacteriosis, staphylococcosis, Glasser’s disease, streptococcosis, actinobacillary pleuropneumonia, atrophic rhinitis, urinary infections, skin and soft tissue infections caused by pathogens sensitive to the components of the medication.
Amoxygard WS is administrated orally for 3 to 5 days:
|
Species |
Route of administration |
Dosage |
Treatment regimen |
Note |
|
Pigs |
Orally with drinking water, milk, or feed |
0,8 to 2 g/100 kg of the animal body weight |
Two times a day, 3 to 5 days |
Amoxigard WS is completely dissolved, when introducing 20 g of the drug in at least 7 liters of water. During treatment, the treatment solution should be the only source of drinking |
|
Poultry |
Orally with drinking water |
4 g/100 kg of the bird body weight |
3 to 5 days |
Hypersensitivity of an animal to penicillin family antibiotics and to other drug components. Avoid using Amoxigard WS in laying hens (with eggs used for human consumption) and in replacement chicks less than 14 days before egg laying starts, as the active ingredients of the drug accumulates there.
Avoid using Amoxigard WS concurrently with other penicillin family drugs, chloramphenicol, macrolides, sulfonamides, and tetracyclines
Pigs can be slaughtered for human consumption not earlier than 3 days, poultry - not earlier than 7 days after Amixygard WS was administered for the last time. In the case of forced slaughter of animals and poultry before the established deadlines, the meat can be used for feeding carnivores.
3 years from the date of manufacture; after first opening - 7 days
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