Azitronit

Hitting targets
Cattle
Small cattle
Pets
Swine
Azithromycin, lidocaine

The first azithromycin-based antibiotic for treatment and prevention of bacterial infections in animals

The next-generation antibiotic

Targeted action1

Protects up to 7 days after the last injection2

Improves the condition of the animal within the first 10-12 h3


  • Description
  • The first highly effective and safe azithromycin-based antibiotic in Russia used for treatment and prevention of respiratory, gastrointestinal and other infections of livestock animals, cats and dogs.
    Appearance: a clear colorless to yellow liquid.
    Available as a sterile solution filled in 100 mL glass vials.



  • Composition
  • Composition
    1 ml Azitronit = 100 mg azithromycin
  • Pharmacological properties
  • Pharmacological properties

    Azithromycin, as a part of the veterinary drug Azitronit – an antibiotic of macrolide group, azalides subdivision, broad-spectrum, taking bacteriocidal / bacterial growth-inhibitory effect on gram-negative (Actinobacillus lignieresi, Haemophilus spp, Moraxella spp, Bordetella spp, Campylobacter spp, Legionella pneumophila, Salmonella spp, Escherichia spp) and gram-positive bacteria (Listeria spp, Staphylococcus aureus, Staphylococcus spp, Streptococcus spp, Streptococcus pneumoniae, Streptococcus pyogenes, Enterococcus faecalis, Erysipelothrix insidiosa) and some anaerobic bacteria (Сlostridium perfringens, Fusobacterium spp), Pasteurella (Mannheimia) haemolytica, Pasteurella multocida, Haemophilus parasuis, micoplasma (Mycoplasma pneumoniae), Chlamydia pneumoniae, spirochetes (Borrelia spp.).

    Azithromycin mode of action is connected with inhibition of protein biosynthesis by bacteria ribosome (peptide bonds between amino acids and peptide chain is getting broken).

    Azithromycin exerts postantibiotic effect – persistent inhibition of bacterial activity after their short-term contact with anti-infective drug. The basis of the effect consists of irreversible changes in microorganism ribosome this translates to stable translocation block. Due to this general antibacterial action of the veterinary drug is getting strengthened and extended, lasting for the term, required for resynthesis of new functional protein of microbial cell.

    Azithromycin absorbs well and splits up in body tissues, reaching high concentration, which is in large excess over blood plasma concentration. High antimicrobial activity is achieved due to azithromycin ability to penetrate and accumulate intracellularly in leucocytes (polymorphonucleocytes and monocytes / macrophages), by which it is transported to area of inflammation, which results in antibiotic concentration 6 times higher in area of inflammation in comparison to intact tissue.

    Lidocaine belongs to the local anesthetic drugs. The mechanism of local anesthetic effect is to stabilize the neuronal membrane, reducing its permeability to sodium ions, thus preventing action potential and conduction of impulses. Antagonism with calcium ions is possible. Rapidly hydrolyses in the weak alkaline medium of tissue and is valid for 60-90 min after a short latent period. The activity is reduced if inflammation (tissue acidosis) occurs. Effective in all types of local anesthesia. Dilates blood vessels. Not irritates tissue.

    After intramuscular administration absorbs quickly (5-15 min), 50-80% is associated with proteins in the plasma, distributed in well-perfused organs, including kidneys, lungs, liver, heart, and penetrates into adipose tissue. Lidocaine is metabolized in the liver. About 90% of the administered dose is excreted in the form of metabolites and 10% is unchanged, the predominant route of excretion is by the kidneys.

     

    THE BROADEST RANGE OF ACTION

    Azitronit has a broad range of action. It inhibits more than 30 pathogens, which is more than 2 times higher than the range of other modern macrolide drugs.

    Azitronit eng.png

    An effect on more than 30 pathogens is proved




  • Indications
  • Indications

    Azithromycin, as a part of the veterinary drug Azitronit – an antibiotic of macrolide group, azalides subdivision, broad-spectrum, taking bacteriocidal / bacterial growth-inhibitory effect on gram-negative (Actinobacillus lignieresi, Haemophilus spp, Moraxella spp, Bordetella spp, Campylobacter spp, Legionella pneumophila, Salmonella spp, Escherichia spp) and gram-positive bacteria (Listeria spp, Staphylococcus aureus, Staphylococcus spp, Streptococcus spp, Streptococcus pneumoniae, Streptococcus pyogenes, Enterococcus faecalis, Erysipelothrix insidiosa) and some anaerobic bacteria (Сlostridium perfringens, Fusobacterium spp), Pasteurella (Mannheimia) haemolytica, Pasteurella multocida, Haemophilus parasuis, micoplasma (Mycoplasma pneumoniae), Chlamydia pneumoniae, spirochetes (Borrelia spp.).

    Azithromycin mode of action is connected with inhibition of protein biosynthesis by bacteria ribosome (peptide bonds between amino acids and peptide chain is getting broken).

    Azithromycin exerts postantibiotic effect – persistent inhibition of bacterial activity after their short-term contact with anti-infective drug. The basis of the effect consists of irreversible changes in microorganism ribosome this translates to stable translocation block. Due to this general antibacterial action of the veterinary drug is getting strengthened and extended, lasting for the term, required for resynthesis of new functional protein of microbial cell.

    Azithromycin absorbs well and splits up in body tissues, reaching high concentration, which is in large excess over blood plasma concentration. High antimicrobial activity is achieved due to azithromycin ability to penetrate and accumulate intracellularly in leucocytes (polymorphonucleocytes and monocytes / macrophages), by which it is transported to area of inflammation, which results in antibiotic concentration 6 times higher in area of inflammation in comparison to intact tissue.

    Lidocaine belongs to the local anesthetic drugs. The mechanism of local anesthetic effect is to stabilize the neuronal membrane, reducing its permeability to sodium ions, thus preventing action potential and conduction of impulses. Antagonism with calcium ions is possible. Rapidly hydrolyses in the weak alkaline medium of tissue and is valid for 60-90 min after a short latent period. The activity is reduced if inflammation (tissue acidosis) occurs. Effective in all types of local anesthesia. Dilates blood vessels. Not irritates tissue.

    After intramuscular administration absorbs quickly (5-15 min), 50-80% is associated with proteins in the plasma, distributed in well-perfused organs, including kidneys, lungs, liver, heart, and penetrates into adipose tissue. Lidocaine is metabolized in the liver. About 90% of the administered dose is excreted in the form of metabolites and 10% is unchanged, the predominant route of excretion is by the kidneys.

     

    THE BROADEST RANGE OF ACTION

    Azitronit has a broad range of action. It inhibits more than 30 pathogens, which is more than 2 times higher than the range of other modern macrolide drugs.

    Azitronit eng.png

    An effect on more than 30 pathogens is proved




  • Dosage and route of administration

    Azitronit shall be administered intramuscularly to cattle, small ruminants and pigs in a dose of 1 mL per 20 kg of animal body weight (5 mg of azithromycin per 1 kg of animal body weight), once daily, for 2 days. If required, injection shall be repeated.

    Azitronit is administered to dogs and cats intramuscularly and subcutaneously in a dose of 1 ml per 10 kg of body weight (10 mg of azithromycin per 1 kg of animal body weight) once a day during 3-5 days.

    REACTIVE PROTECTION WITHIN 7 DAYS UPON THE LAST INJECTION

    Upon a single injection, Azitronit reaches its maximum concentration within the first 30 minutes. Thus, azithromycin, which has an extremely high distribution capacity, is concentrated in the area of inflammation; this leads to the maintenance of the total activity in the lungs for up to 7 days.



    The diagram of pharmacokinetics of Azitronit

    Azik1.png

    Antibacterial activity in the lungs up to 7 days


    A diagram of correlation of azithromycin in plasma and tissues

    Azik2.png

    The Levels of azithromycin in tissues and inside cells are greater than in plasma up to 100 times.

     


  • Dosage and route of administration
  • Dosage and route of administration

    Azitronit shall be administered intramuscularly to cattle, small ruminants and pigs in a dose of 1 mL per 20 kg of animal body weight (5 mg of azithromycin per 1 kg of animal body weight), once daily, for 2 days. If required, injection shall be repeated.

    Azitronit is administered to dogs and cats intramuscularly and subcutaneously in a dose of 1 ml per 10 kg of body weight (10 mg of azithromycin per 1 kg of animal body weight) once a day during 3-5 days.

    REACTIVE PROTECTION WITHIN 7 DAYS UPON THE LAST INJECTION

    Upon a single injection, Azitronit reaches its maximum concentration within the first 30 minutes. Thus, azithromycin, which has an extremely high distribution capacity, is concentrated in the area of inflammation; this leads to the maintenance of the total activity in the lungs for up to 7 days.



    The diagram of pharmacokinetics of Azitronit

    Azik1.png

    Antibacterial activity in the lungs up to 7 days


    A diagram of correlation of azithromycin in plasma and tissues

    Azik2.png

    The Levels of azithromycin in tissues and inside cells are greater than in plasma up to 100 times.

     


  • Restrictions
  • Restrictions

    Slaughter of cattle and sheep should be done not sooner than in 45 days, swine – in 35 days after the last administration of the veterinary drug. Meat of animals, compulsorily slaughtered until the indicated period, can be used for fur-bearing animal feeding.

      

  • Publications
  • Publications
  • Treatment regimen

Back to the list