Amoxicillin trihydrate, the active substance of Amoxicliliin 150, is a semisynthetic penicillin-type antibiotic with a broad spectrum of antimicrobial activity. The mechanism of action of the drug is as follows: it disrupts the process of mucopeptide (a component of microbial cell wall) synthesis by inhibiting transpeptidase and carboxypeptidase activity, which leads to disruption of osmotic balance and destruction of the microbial cell. Amoxicillin is very effective against most Gram-positive and Gram-negative microbes including: Actynomyces spp., Bacillus anthracis, Clostridium spp., Corynebacterium spp., Erysipelothrix rhusiopathiae, Listeria monocytogenes, Staphylococcus spp., Escherichia coli, Haemophilus spp., Pasteurella spp., Salmonella spp., Streptococcus spp, Actinobacillus spp., Proteus mirabilis, Leptospira spp.
Following parenteral injection, amoxycilline trihydrate concentration reaches its peak after 1-2 hours and remains at therapeutic level for 48 hours. The antibiotic is eliminated mostly unchanged with urine and feces